脾萎缩伴暴发性肺炎球菌败血症

ATROPHY OF THE SPLEEN COMPLICATED WITH OVERWHELMING FNEUMOCOCCAL BACTEREMIA

本文报告1例脾萎缩伴暴发性肺炎球菌败血症、脑膜炎、播散性血管内凝血(DIC)及华-弗氏综合征。血培养分离出肺炎球菌。尸体解剖发现脾萎缩、双侧肾上腺出血及坏死。显微镜检查有肺炎、脑膜炎、DIC及华-弗氏综合征的组织学证据。

The authors reported a case of overwhelming pneumococcal infection in a hypo-splenic adult.The patient was treated with ten million units of aqueous penicilling G.but there was no effect.He died 28 hours after admission.Streptococcus pneumo-niae was isolated from the blood culture.Autopsy was performed 6 hours after death. The spleen was found to be atropluc and the weight was 100g. Bilateral adrenal hemorrhagic necrosis was found. Microscopic examination demonstrated evidence of p-urulent pneumonia, meningitis, disseminated intravascular coagulation and Waterhouse-Friderichsen syndrome.The pathogenetic mechanism,early detection and prevention a-re discussed