小儿卵黄囊瘤

YOLK SAC TUMUR IN CHILDREN

本院1966年～1989年共收治小儿卵黄囊瘤37例,经血清甲胎蛋白(AFP)测定,光镜确定诊断又通过10例电镜观察,8例AFP免疫组化观察,文献复习,本文支持Teilum提出该瘤来源于卵黄囊瘤背壁的全能性生殖细胞的组织发生观点;1.胚胎卵黄囊有合成AFP能力,本文意儿血清AFP明显升高,免疫酶标可作AFP定位。2.超微结构观察:肿瘤形态与妊娠7周卵黄囊相似,电镜下可见到上皮性及间叶性成份相当于胚外内胚层及胚外中胚层成份。

37 cases of yolk sac tumor were treated in our hospital from 1966-1989. Serum AFP were measured. The diagnosis of yolk sac tumor was confirmed by light microscope, 10 cases were further examined with electron microscope and 8 cases with AFP immunohistochemistry study. Related literature reviewed. These studies confirm the concept suggested by Telium. i. e. histogenesis of the tumor arising from germ cell differentiating along dorsal wall of yolk sac.1. AFP had been synthesized in yolk sac of embryo. On our study AFP elevated predominately and had been localized by immunoenzymatic labelling PAP methods.2. Electron microscope examination showed that morphology of this tumor is similar with normal human yolk sac at 7 weeks gestation and those finding demonstrated epithilial and mesothelial element is the same as the extia-embryonic endoderm and mesoderm.The terminology of this tumor, the associated relation with teratoma and practice of immunohistochemistry have been discussed