联苯苄唑的药效学研究实验室抗真菌活性测定

RESEARCH INTO PHARMACODYNAMICS OF BIFONAZOLE

联苯苄唑是一种新的咪唑类衍生物,具有广谱抗真菌作用。本实验采用100株临床常见的真菌作了MIC测定。这些菌株对联苯苄唑普遍敏感,79%的菌株MIC≤4μg/ml。MIC值的大小受接种菌量的影响,接种量越大,MIC值越大。通过实验对比。

Bifonazole is a new imidazolyl derivative, with broad spectrum anlimycotic activity. In our experiment, 100 strains of common dermatophytes in clinical practice were used to evaluate the MIC of Bifonazole. All the species tested, were sensitive to this agent, and the MIC values of 79% of strains were under 4g/ml. The MIC value was influenced by inoculum size, the larger the inoculum size, the larger the MIC value. It was found that the efficacy of Bifonazole is comparable to Mico-nazole