氟比洛芬酯对炎症痛大鼠血儿茶酚胺及β-内啡肽水平的影响

Effect of Flurbiprofen axetil on the plasma catecholamine and β-EP level in the inflammatory painful model formalin-induced rats

目的:探讨氟比洛芬酯用于超前镇痛的作用机制,为其更好的用于围术期疼痛治疗提供理论依据。方法:选择Wistar大鼠24只随机分为4组(6只/组):I组(生理盐水对照组)大鼠右后脚趾部皮下注射5%福尔马林溶液0.1ml致痛,之前10min腹腔注射生理盐水溶液2m1。II组(即刻镇痛组)致痛即刻腹腔注射氟比洛芬酯50mg/kg溶液2ml。Ⅲ、Ⅳ组(超前镇痛低、高剂量组)致痛之前10min腹腔注射25、50mg/kg氟比洛芬酯2m1。分别于致痛后1h、12h取血检测E、NE及β-EP水平。结果:与I组比较,致痛后1、12h血浆E、NE水平II、Ⅲ、Ⅳ组均降低(P<0.05),且Ⅳ组低于Ⅲ组(P<0.05);血浆β-EP水平II、Ⅲ、Ⅳ组均升高(P<0.05),且Ⅳ组高于Ⅲ组(P<0.05)。结论:氟比洛芬酯抗伤害性感受作用包含了中枢类阿片活性机制。

Objective： To explore the analgesic mechanism of the Flurbiprofen axetil . Methods ： Rats were randomized to either Ⅰ of Ⅳ groups （n=6 rats for each group） ： Group Ⅰ received a intraperitoneal injection of 2 ml of normal saline solution 10min prior to intraplantar injection of 0.1 ml of 5% formalin solution; Group Ⅱ received a intraperitoneal injection of 2 ml of 50mg/kg flurbiprofen axetil while intraplantar injection of 0.1 ml of 5% formalin solution,Group Ⅲ , Ⅳ received a intraperitoneal injection of 25,50mg/kg 2 ml of flurbiprofen axetil respectively prior to intraplantar injection of 0.1 ml of 5% formalin solution. The levels of plasma E,NE and β- EP were measured respectively. Results ：Compared to group Ⅰ , the level of plasma E,NE were significantly less in those of group Ⅱ, Ⅲ ,Ⅳ ,while that of group Ⅳ were less than group Ⅲ significantly （P〈 0.05） ; plasma β-EP was significantly more in those of group Ⅱ, Ⅲ ,Ⅳ ,while that of group Ⅳ were more than group Ⅲ significantly （all P〈0.05） . Conclusion：The analgesic of Flurbiprofen axetil also probably superimposing on the effect of peripherd and central nervous system.