摘要
目的:探讨hs-CRP及NT-proBNP在慢性肺源性心脏病(PHD)中的变化及其意义。方法:将97例慢性阻塞性肺疾病(COPD)患者分为3组,检测单纯COPD组(A组28例)、COPD并发PHD代偿期组(B组36例)和COPD并发PHD失代偿期组(C组33例)hs-CRP及NT-proBNP值及COPD并发失代偿期PHD患者治疗后hs-CRP及NT–proBNP值。结果:3组患者hs-CRP及NT-proBNP值有极显著性差异(P<0.01),hs-CRP及NT-proBNP值为:C组>B组>A组。COPD并发失代偿期PHD患者治疗前与治疗后比较有极显著性差异(P<0.01)。结论:hs-CRP水平增高与PHD的发生、发展显著相关,对判断COPD患者病情及预后有指导意义。NT-proBNP浓度能较好反应COPD患者是否并发PHD及心功能状态。
Objective：To study the change and the significance of hs-CRP and NT-proBNP in the patients with chronic pulmonary heart disease（PHD）. Methods： We recruited 97 patients in the same period after they re- ceived a diagnosis of COPD and divided them in to 3 groups. Group A contained 28 patients who had pure COPD. Group B contained 36 patients who had COPD, combined with chronic pulmonaryheart disease during compensatory stage. Group C contained 33 patients who had COPD combined with chronic pulmonary heart disease during decom pensatory stage. We measured hs-CRP and NT proBNP in plasma in these 97 patients and then analyzed the differ- ences of its level among the 3 groups. Results： There were significant differences among hs-CRP and NT-proBNP levels in plasma of the 3 groups （P〈0.01）. Each group of COPD patients hs-CRP, NT- proBNP serum level were： C group〉 B group〉 A group. After the therapy, the hs-CRP, NT-ProBNP serum levels significantly decreased with statistically differences （P〈0.01）. Conclusion： The increased hs-CRP levels are correlated with the occurring and developing of chronic pulmonary heart disease. The measurement of plasma NT-proBNP levels in patients with COPD can be used to identify whether they are combined with chronic pulmonary heart disease or heart insufficiency or not.
出处
《陕西医学杂志》
CAS
2012年第9期1223-1225,共3页
Shaanxi Medical Journal
