滋水平肝法治疗高血压性肾损害的临床研究

Clinical Observation of Zishui Pinggan Method on Treating Blood Pressure Renal Damage

目的:观察滋水平肝法合西药治疗高血压性肾损害的临床作用。方法:符合高血压性肾损害诊断标准的住院患者。按随机平行对照法分为两组,治疗组90例,西医治疗基础上加用滋水平肝饮中药,对治疗前后相关数据进行比较。结果:在高血压肾损害CKD1～4期(Ccr≥15ml/min)的患者中,治疗组的总有效率为82.28%,对照组总有效率为60.38%(P<0.01);在CKD5期(Ccr<15ml/min)的患者中,两组的显效不明显,但治疗组的有效率高于对照组,(P<0.05)。说明滋水平肝法为主治疗高血压性肾损害CKD1～4期的患者疗效显著优于西医治疗,对CKD5期的患者疗效亦好于单纯西医治疗,在一定程度上延缓了肾功能进展速度,推迟了透析开始时间。两组治疗后收缩压、舒张压均显著下降,差异显著(P<0.01),组间比较差异无显著性(P>0.05)。治疗组治疗后SCr、BUN、UA、Hgb、Ccr诸项,均获得了显著改善(P<0.01),且治疗后的上述指标治疗组较对照组均有显著差异(P<0.05,P<0.01)。结论:滋水平肝法可能有调节免疫功能,改善肾脏微循环,调节血管活性物质,减少尿蛋白,从而达到修复肾小管上皮细胞,改善肾小球功能,保护肾脏的作用。

Objective： To observe the clinical effect of Zishui Pinggan Method for treating high blood pressure renal damage. Methods： Complying with hypertensive renal damage diagnosis standard hospitalized patients. According to random parallel con- trast method, patients were divided into two groups, the treatment group was 90examples, the control group was 60examples, the control g/oup treated by common western medicine, and the treatment group treated with Zishui Pinggan Decoction on the ba- sis of western medicine. The relevant treatment data were compared. Results ： In hypertensive renal impairment CKD1 - 4 （ Ccr quartile 15ml/min） patients, the total effective rate of the treatment group were 82. 28% and the total effective rate was 60. 38, （P〈0. 01 ） ; in CKD5period （Ccr〈 15m 1/rain） patients, the two groups of powerfully not obvious, but the treatment group of ef- ficient higher than those in the control group, （P〈005）. Zishui Pinggan Method gave priority to treat high blood pressure renal damage, curative effect was significantly better than western medicine therapy to CKD1 -4patients, CKDSperiod of patients also had good curative effect with pure western medicine therapy, and to some extent, delaying the progress of kidney pace, delayed the start time of dialysis. After treating, systolic blood pressure, diastolic pressure of the two groups were decreased significantly （P〈 0. 01 ）, there were no significant differences between the two groups （P〉0. 05）. BUN, SCr, UA, Hgh Ccr of the treat- ment group all won significant improvement （ P〈0. 01 ）, there were significantly differences （ P〈0. 05, P〈0. 01 ） between the treatment group and the control group. Conclusion： Zishui Pinggan Method can regulate immune function, improve microeircula- tion, regulate active substances of blood vessels, reduce urine protein, thus achieve the repair renal tubular epithelial cell, im- prove the kidney glomerular function, thereby protect kidney from damage.