血微、常量元素水平与儿童支气管哮喘的相关性研究

Study of relationship between trace and major elements in blood of children with asthma

【目的】观察支气管哮喘患儿全血锌、铁、钙、镁、铜、铅、锰、硒等微、常量元素含量的变化,并探讨其在支气管哮喘发病机制中的意义。【方法】采用原子吸收光谱法检测1 986例支气管哮喘患儿和856例正常对照组儿童全血锌、铁、钙、镁、铜、铅、锰、硒8种元素含量,并对检测结果作比较分析。【结果】支气管哮喘患儿组锌、铁和钙含量较正常对照组低,血铅含量较正常对照组高,两组间差异有统计学意义(P<0.05);而铜、镁、硒、锰两组间差异无统计学意义(P>0.05)。在哮喘的急性发作期,血锌、钙含量低于缓解期(P<0.05)。【结论】锌、铁、钙缺乏,铅暴露增加,是造成哮喘患儿免疫功能减低、免疫调节紊乱的重要原因,在治疗中需适当补充锌、铁、钙,减少铅暴露。

[Objective] To observe the contents change of zinc, ferrum, calcium, magnesium, copper,lead,manganese and selenium in blood of children with asthma,and explore significance in pathogenesis. [Method] 1 986 children with asthma were selected as observing group and 856 normal children were randomly chosen as control. Serum zinc, ferrum, calcium,magnesium,copper,lead,manganese and selenium were detected and compared between the two groups. [Results] Serum zinc,ferrum and calcium in the asthma group were obviously lower than those in the control group,and serum lead in the asthma group was obviously higher than that in the control group （P〈0.05）. There were no significance differences between the two groups of serum copper, magnesium, selenium, manganese （P all〉0.05）. Asthma in an acute attack, blood content of zinc,calcium were lower than those in remission（P〈0.05）. [Conclusion] Microelement zinc,ferrum and calcium deficiency and increased lead plays an important role in the occurrence and development process of children asthma,which may be an important reason for immune function reduction and immune regulation disturbance. More attention should be paid to the relationship between microelement in blood and the prevention and the cure of excessive lead when we treat the children with asthma.