孕妇血清钙锌及CA125水平与胎膜早破的关系

CA125,serum calcium or zinc in pregnant women with the premature rupture of membranes

目的:研究孕妇缺钙缺锌及CA125水平升高是否导致胎膜早破(PROM)。方法:选取2010年5月至2011年6月我院收治的150例PROM孕妇为观察组,对照组为同孕周150例无PROM的健康孕妇,观察组在诊断为胎膜早破后立即抽取外周血2mL,对照组于入院时采血,测定两组患者中血清钙锌及CA125水平。结果:PROM孕妇血清钙锌含量明显低于对照组(P<0.05)。PPOM组孕妇产前血清CA125水平明显高于对照组(P<0.05)。结论:PPOM患者血清钙锌含量明显降低,血清CA125水平明显增高,提示孕妇血清中钙锌及CA125水平与胎膜早破有关,可以指导临床孕妇规范补充钙锌制剂,检查CA125水平升高,应注意患者是否有炎症发生,及时干预炎症,防止PROM的发生。

Objective： To investigate relationship between serum Zinc,Calcium,CA125 level and the premature rupture of membranes （PPOM） in pregnant women.Methods： 150 cases of patients with premature rupture of membranes（PROM） were randomly assigned to observation group, and 150 healthy pregnant women to control group.we collected 2 mL of peripheral blood immediately when premature rupture of membranes were diagnosed , 2 mL of periphera blood were collected when healthy pregnant women were in hospital.serum calcium or zinc content and CA125 levels were analysed in both groups. Results： serum calcium zinc content in the pregnant women with PROM were significantly lower than in the the control group （P 〈 0.05）. Serum CA125 level in in the pregnant women with PROM were obviously higher than in the control group （P 〈 0.05）. Conclusion： Our study suggested that decline of serum calcium or zinc content, and rising of serum CA125 level were related to PROM. Calcium or zinc preparations could be administrated according to serum calcium or zinc content in pregnant women., we should pay attention to whether the inflammation occurs in pregnant women when serum CA125 level increases, and timely intervene inflammation, to prevent the occurrence of PROM