鸦胆子油经肝动脉栓塞联合中医辨证治疗晚期肝癌疗效观察

Therapeutic Effect of Percutaneous Transhepatic Artery Embolism with Fructus Bruceae Oil Emulsion and Oral Use of Chinese Medicine for Late Liver Cancer

【目的】观察鸦胆子油经肝动脉栓塞联合中医辨证治疗晚期肝癌的临床疗效。【方法】将74例晚期肝癌患者随机分为2组,治疗组38例采用经肝动脉灌注鸦胆子油乳合碘油栓塞,对照组36例采用经肝动脉灌注传统化疗药物(吡柔比星+丝裂霉素+卡铂)合碘油栓塞。介入前后2组均给予中医辨证治疗。观察2组的实体瘤疗效、生存质量改善情况、生存期疗效和毒副作用。【结果】治疗后2组的近期疗效、生存期疗效比较,差异均无统计学意义(P>0.05);但治疗组的生存质量改善情况明显优于对照组,患者介入后发生中度以上发热、消化道反应、骨髓抑制及肝功能损害等毒副作用的比例显著少于对照组,差异有统计学意义(P<0.05)。【结论】鸦胆子油经肝动脉栓塞联合中医辨证治疗晚期肝癌,能有效地改善肝癌患者的临床症状,提高患者的生存质量,减轻毒副反应。

Objective To observe the therapeutic effect of percutaneous transhepatic artery embolism with Fructus Bruceae oil emulsion and oral use of Chinese medicine for late liver cancer. Methods Seventy-four late liver cancer patients were randomized into treatment group （N = 38） and control group （N = 36）. Both groups were given oral use of Chinese medicine based on syndrome differentiation before and after intervention. Meanwhile, the treatment group received percutaneous transhepatic artery embolism with Fructus Bruceae oil emulsion, and the control group received percutaneous transhepatic artery embolism with chemotherapeutics （pirarubicin, mitomycin and carboplatin） and iodinated oil. The changes of solid tumor mass, quality of life and survival time as well as the toxic and side effects were observed. Results After treatment, the differences of short-term effect and survival time were insignificant between the two groups （ P 〉 0.05 ）. However, the improvement of life quality in the treatment group was superior to that in the control group, the incidences of moderate and severe fever, adverse reaction in digestive tract, bone marrow depression and injury of hepatic function were lower than those in the control group （P 〈 0. 05 ）. Conclusion Percutaneous transhepatic artery embolism with Fructus Bruceae oil emulsion and oral use of Chinese medicine are effective for the treatment of late liver cancer through relieving the clinical symptoms, improving life quality and reducing toxic and side effects.