白细胞介素-32研究进展

Research progress of interleukin-32

白细胞介素-32（IL-32）是新近发现的一种细胞因子，体内外研究证明，它能通过抑制核转录因子-κB（NF—κB）、信号传导及转录激活因子3等通路抑制结肠癌及黑素瘤细胞的生长，促进其凋亡。此外，在慢性髓细胞性白血病、肉瘤、前列腺癌中能够通过不同的途径抑制肿瘤生长。

] Interleukin-32 is a newly descovered cytokine. In vivo and in vitro studies show that it inhibits the proliferation and induces apoptosis of colon cancer and melanoma by inhibiting NF-KB and signaling and transcription activated factor 3 pathways. In addition, IL-32 suppresses tumor growth in different ways in chronic myelogenous leukemia, sarcoma and prostate cancer.