摘要
目的:观察氨溴索注射液对急性放射性肺炎的预防作用。方法:72例不能手术的原发性肺癌患者随机分为治疗组36例与对照组36例。采用适形放射治疗技术,总剂量60Gy~64Gy,V_(20)限制在20%~30%;治疗组从放疗开始到放疗结束应用氨溴索注射液每天40mg,bid,静脉点滴;对照组单纯放疗。结果:治疗组和对照组放射性肺炎发生例数(率)分别是4(11.1%)和12(33.3%),两组差异有统计学意义(P<0.05),且治疗组无2级及以上放射性肺炎的发生。结论:肺癌患者放疗期间应用氨溴索注射液能有效预防放射性肺炎的发生。
Objective: To study the protection effect of ambroxol injection against radiation pneumonia of lung cancer patients. Methods: Total of 72 patients with primary lung cancer who were inoperable were randomly allocated into treatment group (36 cases) and control group(36 cases). Conformal radiation technology was used with the total dose up to 60Gy -64Gy and V20 limited between 20% - 30%. The patients in treatment group were given ambroxol injection 40mg intravenously bid plus radiotherapy. The patients in control group were given radiotherapy only. Results: The cases(incidence) of radiation pneumonia in the treatment group and control group was 4 ( 11.1% ) and 12 (33.3 % ) respectively with significant difference between these two groups (P 〈 0. 05 ). Radiation pneumonia of grade 2 or above grade 2 was not found in the treatment group. Conclusion: Ambroxol injection administrated during radiotherapy period can effectively prevent the radiation pneumonia occurred in the lung cancer patients.
出处
《肿瘤预防与治疗》
2012年第5期288-290,共3页
Journal of Cancer Control And Treatment
关键词
放射性肺炎
氨溴索注射液
肺肿瘤
放射治疗
Radiation Pneumonia
Ambroxol Injection
Lung Neoplasms
Radiotherapy