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氨溴索注射液预防肺癌放射性肺炎的疗效观察 被引量:3

The Protection Effect of Ambroxol Injection against Radiation Pneumonia of Lung Cancer Patients
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摘要 目的:观察氨溴索注射液对急性放射性肺炎的预防作用。方法:72例不能手术的原发性肺癌患者随机分为治疗组36例与对照组36例。采用适形放射治疗技术,总剂量60Gy~64Gy,V_(20)限制在20%~30%;治疗组从放疗开始到放疗结束应用氨溴索注射液每天40mg,bid,静脉点滴;对照组单纯放疗。结果:治疗组和对照组放射性肺炎发生例数(率)分别是4(11.1%)和12(33.3%),两组差异有统计学意义(P<0.05),且治疗组无2级及以上放射性肺炎的发生。结论:肺癌患者放疗期间应用氨溴索注射液能有效预防放射性肺炎的发生。 Objective: To study the protection effect of ambroxol injection against radiation pneumonia of lung cancer patients. Methods: Total of 72 patients with primary lung cancer who were inoperable were randomly allocated into treatment group (36 cases) and control group(36 cases). Conformal radiation technology was used with the total dose up to 60Gy -64Gy and V20 limited between 20% - 30%. The patients in treatment group were given ambroxol injection 40mg intravenously bid plus radiotherapy. The patients in control group were given radiotherapy only. Results: The cases(incidence) of radiation pneumonia in the treatment group and control group was 4 ( 11.1% ) and 12 (33.3 % ) respectively with significant difference between these two groups (P 〈 0. 05 ). Radiation pneumonia of grade 2 or above grade 2 was not found in the treatment group. Conclusion: Ambroxol injection administrated during radiotherapy period can effectively prevent the radiation pneumonia occurred in the lung cancer patients.
出处 《肿瘤预防与治疗》 2012年第5期288-290,共3页 Journal of Cancer Control And Treatment
关键词 放射性肺炎 氨溴索注射液 肺肿瘤 放射治疗 Radiation Pneumonia Ambroxol Injection Lung Neoplasms Radiotherapy
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  • 1魏友英,贺小俊.沐舒坦防治放射性肺损伤的临床观察[J].癌症进展,2005,3(6). 被引量:4
  • 2乔文波,赵彦辉,赵艳滨.氨溴索在肺癌放疗时对放射性肺损伤保护作用的观察[J].中国肿瘤临床,2004,31(13):735-737. 被引量:6
  • 3乔文波,赵彦辉,王春波,王瑞芝.氨溴索对放射性肺损伤保护作用的实验研究[J].中华放射医学与防护杂志,2006,26(2):137-140. 被引量:5
  • 4Higgins J, Green S. Cochrane Handbook for Systematic Review of Interventions Version 5. 1. 0 [updated March 2011] [Z]. The Cochrane Collaboration, 2011.
  • 5Available from www. cochrane hand - book. org. Xia DH, Xi L, Xv C, et al. The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor betal and tumor necrosis factor alpha [ J]. Med Oncol, 2010, 27 (3): 697-701.
  • 6Li J, Wang G, Sun X. Transforming growth factor ~ regulates ~ - catenin expression in lung fibroblast through NF - KB dependent pathway [J]. Int J Mol Med, 2014, 34 (5) : 1219 -1224.
  • 7Kim JY, Kim YS, Kim YK, et al. The TGF - beta1 dynamics during radiation therapy and its correlaiion to symptomatic radiation pneumonitis in lung cancer patients [ J ]. Radiat Oncol, 2009 (4): 59.
  • 8Gillissen A, Nowak D. Characterization of N - acetyleysteine and ambroxol in anti - oxidant therapy [ J 1. Respir Med, 1998, 92 (4) : 609 -623.
  • 9Xin W, Lei W, Wang H, et al. Perioperative Lung Protection Provided by High-Dose Ambroxol in Patients with Lung Cancer. [ J ]. Cell Biochem Biophys, 2015, 73 (2) : 1-4.
  • 10Wang B, Yang J, Luo D, et al. Complete remission and fatal interstitial pneumonitis related to nab-paclitaxel in refractory small cell lung cancer: A case report and review of the literature [ J ]. Thorac cancer, 2012, 3( 1 ) :84-87.

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