胃癌组织中F框/WD-40域蛋白7和CyclinE蛋白的表达

Expressions of FBXW7 and Cyclin E proteins in gastric carcinoma tissue

目的:研究F框/WD-40域蛋白7(FBXW7)和CyclinE蛋白在胃癌组织中的表达。方法:应用免疫组化SP法检测75例胃癌和25例癌旁正常胃组织中FBXW7和CyclinE蛋白的表达。结果:胃癌、癌旁正常胃组织中FBXW7和CyclinE蛋白阳性表达率差异有统计学意义(χ2=10.606和7.692,P=0.001和0.006)。FBXW7蛋白的表达与胃癌的分化程度(χ2=7.440,P=0.006)、淋巴结转移(χ2=4.688,P=0.030)、TNM分期(χ2=4.601,P=0.032)有关;CyclinE蛋白的表达与胃癌的浸润深度(χ2=4.902,P=0.027)、淋巴结转移(χ2=4.601,P=0.032)、TNM分期(χ2=4.408,P=0.036)有关。胃癌组织中FBXW7与CyclinE蛋白的表达呈负关联(rP=-0.459,P<0.001)。结论:FBXW7和CyclinE可能在胃癌的发生发展中起重要作用。

Aim：To investigate the expressions of F-box/WD repeat-containing protein 7（FBXW7） and Cyclin E in gastric carcinoma.Methods：Immunohistochemistry SP method was used to examine the expressions of FBXW7 and Cyclin E proteins in 75 cases of gastric carcinoma and 25 cases of para-carcinoma normal tissues.Results：The positive expression rates of FBXW7 and Cyclin E proteins in gastric carcinoma and para-carcinoma normal tissues had significant differences（χ2 =10.606 and 7.692,P=0.001 and0.006）,and the expression of FBXW7 in carcinoma tissue was significantly related with the differentiation degree（χ2 = 7.440,P = 0.006）,lymphatic metastasis（χ2 = 4.688,P = 0.030） and the clinical stage（χ2 = 4.601,P = 0.032）.The expression of Cyclin E was significantly related with invasion depth（χ2 = 4.902,P = 0.027）,lymphatic metastasis（χ2 = 4.601,P = 0.032） and clinical stage（χ2 = 4.408,P = 0.036）.The expression of FBXW7 was negatively associated with that of Cyclin E（rP =-0.459,P 〈 0.001） in gastric carcinoma tissue.Conclusion：FBXW7 and Cyclin E may play important roles in the development of gastric carcinoma.