贝那普利联合黄葵胶囊治疗Ⅱ型糖尿病肾病轻中度蛋白尿的临床观察

Clinical observation of using Benazepril combined with Capusulehuangkui to cure mild and medium degree Proteinuria of Type 2 diabeticmephropathy

目的通过使用贝那普利联合黄葵胶囊治疗Ⅱ型糖尿病肾病(DN)轻中度蛋白尿,探讨其对Ⅱ型糖尿病肾病患者尿蛋白及血白蛋白的影响。方法将38例Ⅱ型糖尿病肾病轻中度蛋白尿患者随机分为两组:所有患者采用相同的基础治疗,治疗组在对照组基础上加用贝那普利5～20mg,既有高血压患者每日口服贝那普利10～20mg,控制血压在80～130mmHg(1mmHg=0.133kPa),无高血压患者每日口服贝那普利5mg,黄葵胶囊15粒,3次/d口服,疗程12周。结果两组患者治疗前后24h尿蛋白定量,血白蛋白差异有统计学意义(P<0.05),治疗组治疗前后24h尿蛋白定量,血白蛋白差异有统计学意义(P<0.05)。结论贝那普利联合黄葵胶囊治疗2型糖尿病肾病轻中度蛋白尿,可以明显的降低尿蛋白的产生,提升血白蛋白的含量。

Objective Probe into the effect on urinary protein and AlbuminHumanSerum of patients who have Type 2 diabeticmephropathy by using Benazepril combined with Capusulehuangkui to cure mild and medium degree Proteinuria of Type 2 diabeticmephropathy.Methods Divide 38 mild and medium degree Proteinuria patients of Type 2 diabeticmephropathy into 2 groups randomly,applying basic treatment to all patients;Applying 5~20 mg Benazepril additionally to control group compared to contrast group;patients who have hypertension take orally 10~20 mg Benazepril per day to control blood pressure between 80~130 mm Hg;patients who don’t have hypertension take orally 5 mg Benazepril and 15 Capusuleshuangkui by three times per day with a course of treatment of 12 weeks.Results Urinary protein of two groups was measured 24 hours before and after treatment,difference of Albumin Human Serum has statistical significance（P〈0.05）;Urinary protein of control group was measured 24 hours before and after treatment,difference of Albumin Human Serum has statistical significance（P〈0.05）.Conclusion Benazepril combined with Capusulehuangkui can reduce the generation of urinary protein and enhance the content of AlbuminHumanSerum for the patients of mild and medium degree Proteinuria of Type 2 diabeticmephropathy.