慢性肝病患者血清可溶性细胞间粘附分子-1和透明质酸水平及其意义

Serum Concentration of Soluble Intercellular Adhesion Molecule-1 Hyaluronic Acid and Their Clinical Significance in Chronic Liver Diseases

目的：探讨血清可溶性细胞间粘附分子－１（ｓＩＣＡＭ－１）和透明质酸（ＨＡ）与肝纤维化及肝损害的关系。方法：用ＥＬＩＳＡ法检测正常人、慢性肝炎肝硬化患者血清ｓＩＣＡＭ－１。用ＲＩＡ法测定正常人、慢性肝炎肝硬化患者血清ＨＡ。结果：慢性肝病患者各组血清ｓＩＣＡＭ－１均显著高于正常人，各组间存在显著差异；血清ＨＡ水平在慢性肝炎中度组、重度组、肝硬化组明显高于正常人。在不同临床类型的慢性肝病患者中ＨＡ血清水平也存在显著差异，病情越重，血清ｓＩＣＡＭ－１和ＨＡ水平越高。两者与血清草酰乙酸转氨酶（ＡＳＴ）、总胆红素、球蛋白呈显著正相关，与血清白蛋白呈显著负相关。结论：慢性肝病患者血清ｓＩＣＡＭ－１和血清ＨＡ可作为判断肝纤维化及肝损伤程度的指标。

Purpose: To study the relation between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1),hyaluronic acid (HA) and hepaticfibrosis, liver damage in patients with chronic liver diseases. Methods: Serum sICAM-1 was measured by ELISA in 106 patients with chronic liver diseases and 30 healthy persons. Sserum levels of HA were measured by RIA in 106 patients with chronic liver diseases and 30 healthy persons. Results: Serum levels of sICAM-1 in patien ts with chronic liver diseases were significantly increased, compared with health persons. While serum levels of HA in patients with chronic moderate hepatitis, chronic severe hepatitis and liver cirrhosis were also higher than those in patients with chronic mild hepatitis and healthy persons. The serum levels of sICAM 1, HA in different stages gradually increase with the progression of liver damage. A significantly positive correlation among serum levels of sICAM-1 and AST, total bilirubin, globulin and also serum levels of HA and serum AST, total bilirubin, globulin could be observed. A markedly negative correlation between sICAM-1 and serum albumin,HA and serum albumin were found. Conclusions: (1)Serum levels of sICAM-1 and HA are two clinical markers for determining hepaticfibrosis. (2)Serum levels sICAM-1 and HA my reflect the damage of liver.