丙戌酸钠对小鼠甲基苯丙胺和可卡因行为敏化的影响

Effects of Valproate on Methamphetamine and Cocaine Behavioral Sensitization of Mice

目的:探讨丙戌酸钠(VPA)对甲基苯丙胺(METH)和可卡因致小鼠行为敏化的影响。方法:在甲基苯丙胺和可卡因行为敏化模型中测定小鼠自主活动,研究甲基苯丙胺和可卡因行为敏化的形成、单次或多次丙戌酸钠对急性甲基苯丙胺和可卡因致小鼠高活动性的影响、丙戌酸钠对甲基苯丙胺和可卡因行为敏化的影响。结果:①甲基苯丙胺或可卡因处理可增强小鼠的自主活动,且随着给药次数增加而增强;②丙戊酸钠对急性甲基苯丙胺和可卡因引起的高活动性没有影响;③甲基苯丙胺和可卡因处理后的每小时自发活动量分别为(15 642.7±286.4)和(14 358.9±273.6),而丙戊酸钠预处理后可抑制甲基苯丙胺的行为敏化的形成,对可卡因无影响。结论:甲基苯丙胺和可卡因在行为敏化的形成过程中具有不同的神经机制。这两种精神兴奋剂之间所存在的微小差异可能具有一定的临床意义。

Objective： To explore the effects of valproate on methamphetamine and cocaine behavioral sensitization of mice.Methods： The locomotor activity was measured in the animal model of methamphetamine and cocaine behavioral sensitization.The relative experiments were carried out as below： the influence of methamphetamine and cocaine on behavioral sensitization,the influence of single or multiple injections of valproate on methamphetamine and cocaine induced high-activity,and the influence of valproate on the behavioral sensitization of methamphetamine and cocaine induced high-activity.Results： ①Both methamphetamine and cocaine can enhance the locomotor activity,and the effect increased in pace with the administration numbers;②valproate had no effect on the high activity resulted by acute methamphetamine and cocaine;③The locomotor activities in an hour after the treatment of methamphetamine or cocaine were（15 642.7±286.4） and（14 358.9±273.6） separately,while valproate only inhibited the formation of the behavioral sensitization caused by methamphetamine.Conclusion： Methamphetamine and cocaine have different neural mechanism in the formation process of the behavioral sensitization.The tiny difference of these two psychostimulant maybe has a certain clinical significance.