摘要
目的:探讨重症监护病房(ICU)危重症患者的免疫功能情况。方法:回顾分析我院ICU在2010年1-12月收治的60例患者的临床资料,比较30例APACHEⅡ评分16-25分的患者(观察Ⅰ组)、30例APACHEⅡ评分>25分的患者(观察Ⅱ组)与30例健康体检者的T淋巴细胞亚群、NK细胞活性、补体水平及免疫球蛋白情况。结果:观察Ⅰ组、Ⅱ组与对照组相比较,CD3、CD4、NK细胞活性、IgA和IgM、补体C3水平均有着显著性差异(P<0.05),除IgA显著高外,其他指标均显著低,剩余各指标无显著性差异(P>0.05);观察Ⅰ组与Ⅱ组相比较,CD4细胞活性有显著性差异(P<0.05),其他各指标无显著性差异(P>0.05)。结论:APACHEⅡ评分越高,细胞免疫抑制情况越严重,ICU危重症患者行免疫调节治疗,可能对改善患者预后情况提供一定帮助,对危重症患者的治疗提供一条新的思路。
Objective: To study the changes of immunological function in critically ill patients in ICU.Methods: The clinical data of 60 cases in ICU were retrospectively studied in year 2010,and the cases were divided into two groups according to the APACHEⅡ scores.The counts of T lymphocyte subsets and NK cells,and the levels of immunoglobulins and complement were compared among group Ⅰ(APACHEⅡ score=16-25),group Ⅱ(APACHEⅡ score〉25) and group Ⅲ(healthy people).Results: CD3,CD4,and NK cells were more,the levels of IgM and C3 were lower,and IgA level was higher in groups Ⅰ and Ⅱ versus that respectively in group Ⅲ(all P〈0.05).These indices showed no difference between groups Ⅰ and Ⅱ except for CD4^+ T cell counts(P〈0.05).Conclusion: Higher APACHE scores had impact on the immune function of critically ill patients,and immune regulation therapy might be helpful for these patients in ICU.
出处
《武汉大学学报(医学版)》
CAS
北大核心
2012年第5期690-692,共3页
Medical Journal of Wuhan University
关键词
ICU
危重症
免疫功能
ICU
Critically Ill
Immunological Function