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ICU危重症患者免疫功能临床分析 被引量:1

Clinical Analysis of Immunological Function in Critically Ill Patients in ICU
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摘要 目的:探讨重症监护病房(ICU)危重症患者的免疫功能情况。方法:回顾分析我院ICU在2010年1-12月收治的60例患者的临床资料,比较30例APACHEⅡ评分16-25分的患者(观察Ⅰ组)、30例APACHEⅡ评分>25分的患者(观察Ⅱ组)与30例健康体检者的T淋巴细胞亚群、NK细胞活性、补体水平及免疫球蛋白情况。结果:观察Ⅰ组、Ⅱ组与对照组相比较,CD3、CD4、NK细胞活性、IgA和IgM、补体C3水平均有着显著性差异(P<0.05),除IgA显著高外,其他指标均显著低,剩余各指标无显著性差异(P>0.05);观察Ⅰ组与Ⅱ组相比较,CD4细胞活性有显著性差异(P<0.05),其他各指标无显著性差异(P>0.05)。结论:APACHEⅡ评分越高,细胞免疫抑制情况越严重,ICU危重症患者行免疫调节治疗,可能对改善患者预后情况提供一定帮助,对危重症患者的治疗提供一条新的思路。 Objective: To study the changes of immunological function in critically ill patients in ICU.Methods: The clinical data of 60 cases in ICU were retrospectively studied in year 2010,and the cases were divided into two groups according to the APACHEⅡ scores.The counts of T lymphocyte subsets and NK cells,and the levels of immunoglobulins and complement were compared among group Ⅰ(APACHEⅡ score=16-25),group Ⅱ(APACHEⅡ score〉25) and group Ⅲ(healthy people).Results: CD3,CD4,and NK cells were more,the levels of IgM and C3 were lower,and IgA level was higher in groups Ⅰ and Ⅱ versus that respectively in group Ⅲ(all P〈0.05).These indices showed no difference between groups Ⅰ and Ⅱ except for CD4^+ T cell counts(P〈0.05).Conclusion: Higher APACHE scores had impact on the immune function of critically ill patients,and immune regulation therapy might be helpful for these patients in ICU.
作者 罗克勤 邓虹
出处 《武汉大学学报(医学版)》 CAS 北大核心 2012年第5期690-692,共3页 Medical Journal of Wuhan University
关键词 ICU 危重症 免疫功能 ICU Critically Ill Immunological Function
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