肠道病毒71型实验室诊断研究进展

The developments in the diagnosis of the enteroviruses 71

肠道病毒71型(Enterovirus 71,EV71)为手足口病(Handf,oot and mouth disease,HFMD)和相关疾病的主要病原体,多感染婴幼儿,少数病例可以并发呼吸道感染和心肌炎、无菌性脑膜炎、脑炎、急性弛缓性麻痹等严重疾病,可致残、致死。因此EV71实验室诊断对EV71引起疾病的治疗和防控具有重要意义。本文将从核酸检测、抗体检测及其他检测等三部分对EV71的实验室诊断方法研究进展进行了综述。

Recent outbreaks of human enterovirus 71 （ EV71 ） infection and EV71-associated hand, foot and mouth disease （HFMD） in China have affected millions and potentially lead to life-threatening complications in infants. Furthermore, these outbreaks represent a significant global public health issue in the world. These common infections create a significant burden on our society and heahhcare system. Our understanding of this important group of viral pathogens has increased dramatically in the past decade. The quantitative assay methods for vaccine antigen and neutralizing antibody are the impor- tant research subjects to the development of molecular diagnostic techniques for the detection of the enteroviruses. This re-view discusses recent developments in the diagnosis of the enteroviruses 71.