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NALP3炎性体在沙眼衣原体感染中的作用研究进展

Effects of NALP3 inflammasome on chlamydia trachomatis infection
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摘要 沙眼衣原体具有广泛的致病谱,不仅是感染性致盲的首要病因,也是性传播疾病的主要病原体。持续性炎症反应与沙眼衣原体感染致病密切相关。NALP3炎性体是一种细胞内多蛋白复合物,在Ct感染所致的持续炎症反应中发挥重要作用。本文就NALP3炎性体的结构和功能及其在沙眼衣原体感染中的作用作一综述。 Chlamydia trachomatis which has widely pathogenicity is not only a leading cause of infective blindness, but also the major pathogen of sexually transmitted disease. There is a close correlation between persistent inflammation and Chlamydia trachomatis infection. NALP3 inflammasome, an intracellular multiprotein complex, is playing a key role in persistent inflammation caused by Chlamydia trachomatis infection. The purpose of this review is to summarize the structure and function of NALP3 inflammasome in Chlamydia trachomatis infection.
作者 曹文娟 李忠玉
机构地区 南华大学病原生物学研究所
出处 《微生物学免疫学进展》 2012年第4期67-69,共3页 Progress In Microbiology and Immunology
基金 国家自然科学基金(沙眼衣原体pORF5蛋白功能及其与宿主细胞相互作用的研究30970165 pORF5介导p38MAPK和NALP3信号通路对调控沙眼衣原体炎症反应的机制研究81102230)
关键词 沙眼衣原体 NALP3炎性体 炎症 Chlamydia trachomatis NALP3 inflammasome Inflammation
分类号 R759 [医药卫生—皮肤病学与性病学]
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参考文献24

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微生物学免疫学进展
2012年 第4期

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