人凝血酶原复合物的研究进展

Research progress of human prothrombin complex concentrates

人凝血酶原复合物(Human prothrombin complex concentrate,PCC)是由健康人混合血浆中分离制备的一种血浆蛋白制剂,主要含有依赖于维生素K的凝血酶原(FⅡ)、凝血酶原转化因子(FⅦ)、抗乙型血友病因子(FⅨ)和自身凝血酶原(FX)。在临床上,PCC主要用于治疗乙型血友病和因维生素K缺乏或患肝病而引起的出血症状。近年来,随着PCC分离技术的发展和安全性的提高,PCC的使用量正在逐年增加。本文综述了PCC的制备工艺研究现状、临床使用和安全性。

Human prothrombin complex concentrate（PCC） is a plasma protein product, which is isolated from the plasma pool of healthy people and contains a range of vitamin K-dependent haemostatic factors including factor Ⅱ factor IX and factor X. In clinical application, it is used primarily in the treatment of a range of blood disorders in which patients exhibit low levels of these factors including haemophilia B and those with acquired deficiency of vitamin K-dependent coagulation factors through the use of anticoagulants. Recently, due to the development of separation technology and the improvement of safety,the amount of PCC usage is increased year by year. This article describes the production and research of PCC, as well as its clinical use and safety.