纳米颗粒与生物大分子的相互作用及其生物毒性机制

The interaction between nanoparticles and large biological molecules and their biological toxicity mechanism

纳米颗粒已得到广泛的应用,同时其潜在的毒性及生物学效应也引起了广泛的关注。许多文献证实纳米颗粒对生物体具有毒性作用,但在分子水平上对其毒性机制的研究较少。本文对近年来纳米颗粒与生物大分子相互作用的最新研究进行了综述,包括纳米颗粒与蛋白质、脂类、核酸等生物分子间的相互作用。

Nanoparticles have been extensively applied in many industries and their potential biological toxicity has been fo-cused on too. It is testified in some information that nanoproducts have a potential toxicity to the lives from single to multi-ple cells bodies. But the toxic mechanisms have kept in mystery or been known little about it, especially in biological mo-lecular levels. In this paper, it is to review some recent proceedings dealing with the interaction between nanoparticles and large biological molecules including proteins, nucleic acids and lipids, and some mechanisms described in the recent re-ports are introduced here.