加减四妙散对超重糖耐量减低患者炎症因子的影响

Effect of Modified Simiao Powder on the Inflammatory Factors in Overweig ht Patients with Impaired Glucose Tolerance

目的观察加减四妙散对湿热困脾型超重葡萄糖耐量减低(IGT)患者炎症因子的作用。方法超重IGT患者67例随机分为治疗组35例和对照组32例,治疗组在饮食运动指导的同时给予加减四妙散口服,对照组仅给予饮食运动指导,共观察1个月。比较两组治疗前后临床症状积分、空腹血糖(FBG)、餐后2小时血糖(2hPG)、空腹胰岛素(FINS)、白介素-6(IL-6)、脂联素(ADP)、体重指数(BMI)、胰岛素敏感性指数(IAI)的变化。结果两组患者在中医症状积分上较治疗前均有所改善(P<0.05),治疗组患者BMI、FINS和IL-6水平较治疗前降低,ADP水平升高(P<0.05)。治疗组改善中医症状,降低FBG、FINS、IL-6水平和升高ADP、IAI水平均明显优于对照组(P<0.05)。结论加减四妙散可以通过调节炎症因子水平改善超重IGT患者胰岛素抵抗。

Objective To observe the effect of Modified Simiao Powder on the inflammatory factors in impaired glucose tol- erance （IGT） patients with syndrome of damp-heat encumbering the spleen. Methods Sixty-seven IGT patients were random- ized into treatment group （35 cases） and the control group （32 cases）. The control group was given diet and exercise guidance. Modified Simiao Powder was added in the treatment group. The treatment lasted for one month. The changes of the clinical symptoms, fasting blood glucose （FBG）, 2-hour postprandial blood glucose （2h-PBG）, fasting insulin （FINS）, interleukin-6 （IL-6）, adiponectin （ADP）, body mass index （BMI） and insulin activity index （lAD were compared before and after treat- ment. Results The scores of TCM symptoms were improved in both groups （P＊~0.05）. The levels of BMI, FINS and IL-6 were significantly decreased while ADP increased in the treatment group （P^0.05）. Comparing with the control group, Modi- fied Simiao Powder could significantly improve the scores of TCM symptom, decrease the levels of FBG, FINS and IL-6 and in- crease the levels of ADP and IAI （P（0.05）. Conclusion Modified Simiao Powder can improve the insulin resistance of IGT patients by modulating the inflammatory factors.