乳腺癌超声恶性晕病理基础

Pathological basis of breast cancer malignant halo on ultrasound

目的研究乳腺癌超声恶性晕的病理基础。方法选择经病理证实的乳腺非特殊型导管浸润癌80例，术前确定边界状态，分成恶性晕组和无恶性晕组。用免疫组化方法检测雌激素受体（ER）、孕激素受体（PR）、人内皮生长因子受体（CerB-2）、核蛋白抗体（Ki-67）表达，观察组织分级、有丝分裂记数，记录肿瘤大小、患者年龄及淋巴结转移数目。对乳腺癌边界进行病理观察。对恶性晕标本取材观察组织构成。结果恶性晕组乳腺癌Ki-67表达明显低于无恶性晕组乳腺癌；晕组织构成基础是脂肪组织，内散在脱离癌主体的大块癌组织，大块纤维组织，散在正常小叶和导管。结论恶性晕是乳腺浸润癌的超声特殊表现。

Objective To investigate the pathologic base of breast cancer malignant halo. Methods The status of margin of 80 cases confirmed breast nonspecific invasive ductal cancer by pathology were determined preoperatively. 80 cases were divided into two groups., malignant halo group and non malignant halo group. The estrogen receptor （ER）, progesterone receptor （PR）, human endothelial growth factor receptor （CerB-2）, nuclear protein antibodies （Ki-67） expression were detected by immunohistochemical method. The histological grade, mitotic count and documented tumor size, patient age and the number of lymph node metastases, breast cancer margin on pathology were observed. Halo tissue were drawn from specimens and the tissue structure were observed. Results Ki-67 expression in malignant halo group were significantly lower than those in non malignant halo group. The observing results of the margin status of breast cancer on ultrasound and pathology were consistent. Halo tissue was mainly composed of fatty tissue and scattered clumps of cancerous tissue,fibrous tissue,normal lobular and tubular. Conclusions Malignant halo is a special manifestation of breast cancer on grav-seale ultrasound.