末端糖基化产物抑制剂的研究进展

Research Progress on Inhibitors of Advanced Glycation Endproducts

目前研究表明人体的衰老和糖尿病的一些并发症,都与体内的糖基化反应(美拉德反应)所产生的末端糖基化产物有关。为了延迟体内的糖基化反应,末端糖基化产物抑制剂成为了相关研究领域的热点。为此,从末端糖基化产物的形成原理、病理学危害、抑制机理及天然产物中的抑制剂方面做阐述,并对未来研究领域进行展望。

Advanced glycation endproducts （AGEs）, which are produced by glycation reaction related to the Mallard reaction, are involved in accelerated aging and diabetic complication. A huge body of literature has reported AGE research and developing AGE inhibitors has been a hot topic of intensive studies recently. In this review, we provide an outline of the formation of AGEs, their pathological damage, and the mechanisms underlying the anti-glycation and anti-glycation properties of foodstuffs. Prospects for future direction are also discussed.