摘要
细胞与细胞外基质之间的相互作用在细胞的迁移、分化、凋亡等生理过程中起着重要的作用,细胞铺展作为细胞与细胞外基质作用的第1步,受到了人们的广泛关注.首先阐述了细胞铺展的关键生物动力学过程,对铺展3个不同阶段的特点进行了总结和归纳,并运用力学的观点阐明了细胞铺展的驱动力及驱动机制,详细讨论了聚合力、黏附力以及细胞张力等3种主要作用力在细胞铺展过程中的作用规律以及相应的物理模型.在此基础上,从细胞的黏性流动及力学平衡两个方面出发,简要综述了已有相关研究结果的不足之处,介绍了当前建立细胞铺展动力学模型的主要思路,并探讨了今后面向细胞生物学需求的相关细胞动力学的研究方向.
The interaction between cell and extracellular matrix （ECM） is essential in many cellular processes, such as cell migration, differentiation and apoptosis. As the first step of cell-ECM interaction, cell spreading has been widely investigated. In this review, the biological background of cell spreading process is first introduced, including a brief overview of involved genes and proteins. Polymerization force, adhesive force and membrane tension are introduced in a coherent framework of cell spreading dynamics from mechanics point of view. The existing physical and/or mechanical models are reviewed based on principles of either viscous flow of cells or mechanical equilibrium at cell periphery. We also discuss the modeling approaches, open questions, and potential opportunities of cell spreading dynamics.
出处
《力学学报》
EI
CSCD
北大核心
2012年第5期807-823,共17页
Chinese Journal of Theoretical and Applied Mechanics
基金
中国科学院重点部署项目(KJZD-EW-M01)
中国科学院科研装备研制项目(Y2010031)资助~~
关键词
细胞铺展
肌动蛋白丝
黏着斑
牵拉力
膜张力
黏性流动
cell spreading, F-actin, focal adhesion, traction force, membrane tension, viscous flow
