摘要
目的研究聚丙烯酸树脂Eudragit L100和Eudragit S100(1∶4混合)游离膜的性质,考察其影响因素。方法采用铸膜法制备游离膜,测定聚合物溶度参数、特性黏度、抗张强度和透湿性,筛选聚合物最佳溶剂和增塑剂。结果乙醇制成的游离膜抗张强度最大,丙酮制成的游离膜透湿性最强,乙醇为最佳溶剂;增塑剂可降低游离膜的抗张强度和增加膜的透湿性,邻苯二甲酸二乙酯为最佳增塑剂。结论这些研究可以为包衣液处方筛选和包衣工艺优化提供参考。
OBJECTIVE To investigate the properties of polyacrylic resin Eudragit Ll00-Eudragit S100 （mixed at ratio of 1： 4） free film and its various influencing factors. METHODS The free film was prepared by casting method, and its solubility parameter, intrinsic viscosity, tensile strength and permeability were determined. The optimal solvent and plasticizer were screened. RESULTS The tensile strength of the film prepared by ethanol was maximum, and the permeability of the free fihn made using acetone was the highest, therefore ethanol was the optimal solvent. Plasticizer could decrease the tensile strength and increase the permeability of free film, and diethyl phthalate was the optimal plasticizer. CONCLUSION The present investigation might be helpful for screening coat- ing formulation and optimizing coating process.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2012年第18期1489-1492,共4页
Chinese Pharmaceutical Journal
