摘要
目的:探讨反复自然流产(RSA)与促血管生成素-2(Ang-2)的关系。方法:用免疫组化法检测33例反复自然流产患者和37例健康早孕人工流产妇女的绒毛膜组织中Ang-2的表达水平。结果:自然流产组Ang-2的表达高于人工流产组,差异有统计学意义(P<0.05);两组Ang-2的表达均与年龄无关(P>0.05);自然流产组Ang-2的表达与胚胎孕周呈正相关(P<0.05),而人工流产组Ang-2的表达与胚胎孕周无关(P>0.05)。结论:Ang-2的高表达可能是造成自然流产的原因之一。
Objective： To explore the relationship between recurrent spontaneous abortion （RSA） and angiopoietin -2. Methods： The expression levels of angiopoietin - 2 in chorionic tissues of 33 patients with RSA and 37 healthy early pregnant women receiving artificial abortion were detected by immunohistochemical method. Results ： The expression level of angiopoietin - 2 in spontaneous abortion group was statistically significantly higher than that in artificial abortion group （ P 〈 0. 05 ） ; the expression levels of angiopoietin - 2 in the two groups were not correlated with age （P 〉 0. 05） ; there was a positive correlation between the expression of angiopoietin - 2 and gestational weeks in spontaneous abortion group （ P 〈 0. 05 ）, while in artificial abortion group, the expression of angiopoietin - 2 was not related to gestational weeks （P 〉 0. 05） . Conclusion： High expression of angiopoietin - 2 may be one of the causes of RSA.
出处
《中国妇幼保健》
CAS
北大核心
2012年第27期4253-4255,共3页
Maternal and Child Health Care of China
基金
广西壮族自治区卫生厅科研课题〔Z2009256〕
南宁市科学研究与技术开发计划项目〔201003049C-2〕
