胃癌肝转移患者血清CEA、CA199分布及其临床意义

Distribution of serum CEA and CA199 in patients with gastric cancer live metastases and its clinical significance

目的探讨血清CEA、CA199在晚期胃癌患者中的分布规律以及与临床特征的关系。方法将158例晚期胃癌患者按性别、年龄（≤60岁和〉60岁）、有无腹水、有无肝转移分组，分析患者的血清CEA、CA199浓度水平、阳性率以及与临床特征的关系。结果血清CEA和CA199水平在肝转移患者中明显升高，其均值分别达到（118±78）ng／ml和（391±256）U／ml，差异有统计学意义（P=0．027和0．045），而与年龄、性别和有无腹水无关；肝转移胃癌患者血清CEA、CA199的阳性率也较高，分别达到78．3％和56．5％，差异有统计学意义（P=0．011和0．002），而与患者年龄、性别和有无腹水无关。结论血清CEA、CA199的浓度和阳性率在合并有肝转移的患者中水平较高，与年龄、性别、有无腹水无关。监测其血清CEA、CA199水平及其动态变化有助于较早的发现肝转移。

Objective To investigate the distribution of serum CEA, and CA199 in patients with advanced gastric cancer and their relationship with clinical features. Methods One hundred and fiftyeight cases of advanced gastric cancer were classified by gender, age （ ≤ 60 years, 〉 60 years）, with or without ascites and with or without liver metastasis, the serum CEA, CA199 levels and the positive rate was detected. Results Serum CEA and CA199 levels in patients with liver metastasis were significantly increased, and their average were （ 118 ± 78） ng/ml and （391 ± 256） U/ml, and the differences were significant （P = 0. 027 and 0. 045 ） , the serum levels of CEA and CA199 were independent on age, gender and with or without ascites. The positive rates of serum CEA and CA199 were 78.3% and 56.5% in patients with metastasis, which were elevated, and （P = 0.011 and 0. 002） , which were independent on age, gender and ascites. Conclusions The levels and positive rates of serum CEA and CA199 were higher in gastric cancer patients with liver metastasis, which were independent on age, gender and ascites.