皓首复智丸对痴呆模型大鼠脑损伤组织的修复作用

Morphologic Study on Effects of Haoshou Fuzhi Capsule in Brain Tissue of Rat with Dementia

目的 从形态学角度探讨皓首复智丸 (HSFZC)对痴呆大鼠脑组织的修复作用。方法 应用基底核毁损法 ,将 30只 SD大鼠制成痴呆模型 ,应用光镜、电镜观察 HSFZC治疗组、模型对照组和脑复康药物对照组对痴呆大鼠脑组织形态学影响。结果 模型对照组大鼠脑神经细胞、胶质细胞核周池与内质网相连成网似岛状 ,胞浆内线粒体数目减少而且肿胀 ,线粒体嵴部分脱失 ,部分线粒体内出现髓样环膜小体 ,粗面内质网核糖体脱失现象严重 ,脑组织中毛细血管内皮细胞肿胀 ,血管周围间隙增宽。 HSFZC治疗组脑组织神经细胞核染色质分布均匀 ,线粒体数目增多 ,与对照组比较 P<0 .0 5,线粒体中未出现髓样环膜小体 ,核糖体脱失现象消失。脑复康治疗组神经细胞核染色质疏松 ,线粒体嵴脱失现象仍存在 ,线粒体内仍查见髓样环膜小体 ,但水肿减轻。结论 HSFZC对模型痴呆鼠脑组织损伤有较好的修复作用。

Objective To explore the repairing effects of Haoshou Fuzhi Capsul (HSFZC) in brain tissue of rats with dementia.Method With optical microscope and electron microscope morphologic changes in brain tissue of rat with dementia were observed including 10 rats of model control group and 10 rats of treatment with HSFZC and 10 rats of Naofukang treatment group.Result In model control group,the mitochondria of the neuron and gliacyte showed edema and decreasd in number.Some medullary ring membrane body were found in mitochondria,endothial cells of capillary were edema.In the treatment group with HSFZC,the nucleus chromatin of neuron was well distributed and found mitochondria increasing in number,it is more than control group (P<0.05).The mitochondria in shape was gotlen normal.Endothelial cells of capillary edema phenomenon was disappeared.The Nao fu kang treatment group showed alittle better than control group,but no statistical significance.Conclusion There are some good effects of HSFZC in repairing brain tissue of model rats with dementia. [