呆聪液对老龄痴呆大鼠血清酶及LPO的影响

The Effect of Daicong Solution on the Serum Enzymes in Aged Rat Dementia Model

目的 探讨呆聪液对老龄痴呆大鼠动物模型某些血清酶活性及过氧化脂质 (LPO)的影响。方法 采用双侧电解损毁 2 2月龄大鼠脑基底核法 ,造成动物学习与记忆功能障碍的老龄鼠痴呆动物模型 ,用中药呆聪液灌胃给药 1个月后 ,检测血清中超氧化物歧化酶 (SOD)、胆碱酯酶 (CHE)和单胺氧化酶 (MAO)的活性水平及过氧化脂质的含量。结果 呆聪液可提高老龄痴呆大鼠血清 SOD活性 (P<0 .0 1) ,降低 LPO含量 (P<0 .0 1) ,降低 MAO和 CHE活性 (P<0 .0 1)。结论 呆聪液对氧自由基具有一定的清除作用 ,还可清除 L PO并抑制 CHE与 MAO的活性 ,具有益智抗衰老作用。

Objective To explore the effect of Daicong Sloution in aged rats dementia model. Method The experiment used 22 month old rats whose basal nuclei was destroyed by bilateral electrolytic method as model for aged rats dementia. They were treated with Daicong Solution for a moth. Then the level of superoxide dismulase (SOD),lipid peroxides (LPO),monoamine oxidase (MAO) and cholinesterase (CHE) in the serum was measured. Result Compared with the control,the activity of SOD increased markedly (P<0.01),the content of LPO and activity of MAO and CHE were decreased (P>0.01). Conclusion Daicong Solution is effective in treating the aged dementia. [