期刊文献+

老年房颤患者复律后小剂量胺碘酮口服维持窦性心律的有效性与安全性研究 被引量:1

原文传递
导出
摘要 目的观察老年心房颤动患者复律后小剂量胺碘酮口服维持窦性心律的有效性与安全性。方法将入选的70例老年心房颤动患者转复为窦性心律后随机分为实验组(n=32)和对照组(n=38),实验组口服胺碘酮,对照组口服普罗帕酮治疗。观察两组的疗效及不良反应发生率。结果实验治疗组维持窦性心律的效果明显优于对照组(P<0.05),且两组患者总的不良反应发生率差异无统计学意义(P>0.05)。结论小剂量胺碘酮(100 mg/d)在老年心房颤动患者复律后的窦性心律维持过程中的效果明显优于普罗帕酮,具有良好的有效性与安全性。
出处 《苏州大学学报(医学版)》 CAS 2012年第4期557-558,共2页 Suzhou University Journal of Medical Science
  • 相关文献

参考文献10

  • 1郭继鸿.胺碘酮的现代观点(续)[J].临床心电学杂志,2007,16(3):215-226. 被引量:21
  • 2Sager PT. New advances in class Ⅲ antiarrhythmic drug therapy [ J ]. Curr Opin Cardiol, 2000,15 ( 1 ) :41 - 53.
  • 3Roy D, Talajic M, Dorian P, et al. Amiodarone to prevent recurrence of atrial fibrillation Canadian Trial of Atrial Fi- brillation Investigators [ J ]. N Engl J Med, 2000, 342 (13) :913 -920.
  • 4Gosselink ATM, Crijns HJGM, van Gelder IC, et al. Low- dose amiodarone for maintenance of sinus rhythm after card- ioversion of atrial fibrillation or flutter [ J ]. JAMA, 1992, 267 (24) :3289 - 3293.
  • 5Chun SH, Sager PT, Stevenson WG, et al. Long-term effi- cacy of amiodarone for the maintenance of normal sinus rhythm in patients with refractory atrial fibrillation or flutter [ J ]. Am J Cardiol, 1995,76 ( 1 ) :47 - 50.
  • 6Reinmold SC, Cantillon CO, Friedman PL, et al. Propafenone versus sotalol for suppression of recurrent symptomatic atrial fibrillation [ J ]. Am J Cardiol, 1993,71 (7) :558 -563.
  • 7Kawabata M, Hirao K, Hachiya H, et al. Role of amioda- rone in patients with atrial fibrillation and congestive heart failure[J]. Cardiol, 2011,58(2) :108 - 115.
  • 8马虹.胺碘酮治疗心房颤动再评价[J].中华心律失常学杂志,2005,9(2):133-135. 被引量:36
  • 9Essebag V, Hadjis T, Platt RW, et al. Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardi- al infarction [ J ]. J Am Coll Cardiol, 2003,41 (2) : 249 - 254.
  • 10Kirkutis A, Poviliunas A, Griciene P, et al. Cardiac rate normalization in chronic atrial fibrillation: comparison of long-term efficacy of treatment with amiodarone versus AV node ablation and permanent His-bundle pacing[ J]. Proc West Pharmacol Soc, 2004,47:69 - 70.

二级参考文献17

  • 1Thomas D, Kathofer S, Zhang W, et al. Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels. Br J Pharmacol,2003,140:996-1002.
  • 2Shingawa K, Shiroshita-Takeshita A, Schram G, et al. Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium:insights into the mechanism of the superior efficacy of amiodarone. Circulation,2003,107:1440-1446.
  • 3Haikerwal D, Esler MD, Dart AM. Acute electrophysiologic effects of intravenous amiodarone are independent of a sympatholytic action in humans. J Cardiovasc Pharmacol, 2003,41:760-765.
  • 4Letelier LM, Udol K, Ena J, et al. Effectiveness of amiodarone for conversion of atrial fibrillation to sinus rhythm: a metaanalysis. Arch Intern Med,2003 ,163 :777-785.
  • 5Khan IA, Mehta NJ, Gowda RM. Amiodarone for pharmacological cardioversion of recent-onset atrial fibrillation. Int J Cardiol, 2003,89: 239-248.
  • 6Bernard EO, Schmid ER, SchmidlinD, et al. Ibutilide versus amiodarone in atrial fibrillation: a double-blinded, randomized study. Crit Care Med,2003,31:1031-1034.
  • 7Naccarelli GV,Wolbretted L,Khan M, et al. Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation:comparative efficacy and results of trials. Am J Cardiol,2003,91 (Suppl): 15D-26D.
  • 8Levy S. Amiodarone as a first-line drug in the treatment of atrial fibrillation: the protagonist viewpoint. Cardiovascdrugs Ther, 1994,8: 769 -771.
  • 9Fuster V,Ryde'n LE,Asinger RW,et al,for the Committee to develop Guidelines for the Management of Patients with Atrial Fibrillation Investigators. ACC/AHA/ESC Guidelines for the Management of Patients with Atrial Fibrillation: executive Summary. Circulation ,2001,104:2118-2150.
  • 10Roy D,Talajic M,Dorian P,et al. Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators. N Engl J Med ,2000,342:913-920.

共引文献55

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部