153例宫颈鳞状细胞癌间质分析

A study on the interstitium of squamous cell carcinoma of cervix uteri

通过对 15 3例宫颈鳞癌间质的研究 ,探讨间质变化对患者预后的影响。结果发现淋巴细胞浸润占10 0 % ,浆细胞浸润占 70 .5 9% ( 10 8例 ) ,47.0 6 % ( 72例 )见中性白细胞浸润 ,淋巴细胞与纤维组织均显著高者并不多见仅为 10余例。在与其它器官鳞癌、移行细胞癌的对比中发现纤维组织增生以宫颈鳞癌最多 ,其次为肺鳞癌、食道鳞癌、膀胱鳞癌 ,而膀胱移行细胞癌最少。认为间质细胞主要为淋巴细胞的浸润表示免疫反应 ,浸润增加则预后较好 ;间质纤维组织增生可以抑制肿瘤细胞的转移 ;

Interstitia of squamous cell carcinoma of cervix uteri from 153 patients were studied so as to seach out the relationship between interstitial infiltration and patients' prognosis.The result showed that the lymphocytic,plasmacytic,and neutraphil infiltration was 100%,70.59%,and 47.06%,respectively.Significant proliferation of lymphocyte and fibrous tissue was found in only 10 patients or more.As compared with squamous or transitional cell carcinoma of other organs,fibrous cell proliferation was most frequemtly seen in squamous cell carcinoma of cervix uteri,and secondarily,of the lung,esophagus,and bladder,rarely seen in transitional cell carcinoma of the bladder.It is suggested that domenant infiltration of lymphocyte in the interstitia indicates immuno-reaction to carcinoma and implies a better prognosis,infiltrational proliferation of fibrous tissue has an inhibitory effect on carcinoma cell metastasis,but the growth of interstitial blood vessel will facilitate the proliferation of cancer cell.