姜黄素和安理申联合治疗老年性痴呆研究

Study on effect of combination of donepezil and curcumin in treating old patients with Alzheimer's disease

目的探讨联合应用姜黄素和安理申对老年性痴呆患者认知功能和行为能力的改善作用。方法收集老年性痴呆患者90例,随机分为3个组,姜黄素和安理申联合治疗组30例,安理申治疗组30例,空白对照组30例。空白对照组不使用治疗痴呆药物。3组患者分别在治疗前和治疗3、6个月后进行MMSE评分、ADL评分的测评。结果姜黄素和安理申联合治疗组患者治疗后认知、行为能力较安理申治疗组改善明显(P<0.01)。结论姜黄素和安理申联合治疗对老年性痴呆患者认知、行为能力有显著改善作用。

Objective To investigate the effect of combination of donepezil and curcumin on cognitive function and behav- ioral abilities in treating old patients with Alzheimer＇s disease. Methods Totally 90 patients with Alzheimer^s disease were randomly divided into 3 groups： the group treated with donepezil, group treated with donepezil and curcumin, and control group without any medicine or herb to prevent Alzheimer＇s disease. MMSE scale and ADL scale of the three groups were assessed and compared before treatment and 3 months, 6 months after treatment. Results The cognitive function and behavioral abilities were improved markedly in the group treated with donepezil and curcumin （P〈0.01）. Conclusion Combination of donepezil and curcumin can markedly ameliorate the cognitive function and behavioral abilities in patients with Alzheimer＇s disease.