多发性硬化患者病情演变与tau蛋白关系的研究

Relationship between tau protein and multiple sclerosis

目的探讨神经元损伤的标志物tau蛋白与多发性硬化患者病情演变的关系。方法 48例多发性硬化患者分为复发-缓解组和继发进展组,MSSS和EDSS量表评定疾病严重程度及致残状况。ELISA法测定患者脑脊液和血清总-tau(total-tau,T-tau)蛋白和磷酸化-tau(phospho-tau,P-tau)蛋白浓度。结果复发-缓解组患者脑脊液T-tau蛋白浓度明显高于继发进展组(P=0.01)。多发性硬化患者脑脊液T-tau蛋白与EDSS评分呈负相关(γ=-0.58,P=0.0006)。结论多发性硬化患者病程中脑脊液总tau蛋白浓度的变化,间接反映脑实质损伤的程度。

Objective To investigate the relationship between tau protein and multiple sclerosis （MS）. Methods Cerebrospinal fluid （CSF） and blood samples were collected from 48 patients with multiple sclerosis. Total-tau（T-tau） and phosphor tau （P-tau） concentrations were assayed with ELISA and correlated with clinical characteristics. Results T-tau concentration in CSF was significantly higher in relapsing-remitting （RR） compared to secondary progressive （SP） MS patients （P=0.01）. Ttau in the CSF was negatively correlated to EDSS （γ= -0.58,P=0. 0006）. Conclusion T-tau concentration in CSF of MS patients in the course of disease maybe reflect the degree of parenchymal brain loss.