他达拉非治疗钬激光前列腺剜除术后勃起功能障碍34例疗效观察

Clinical observation of tadalafil for 34 cases with ED after holmium laser enucleation of the prostate

目的评估他达拉非在治疗钬激光前列腺剜除术（HoLEP）后勃起功能障碍（ED）的疗效。方法34例HoLEP术后的ED患者接受为期3个月的他达拉非治疗，治疗后随访6个月。在治疗前后及随访6个月后记录各组患者国际勃起功能指数评分简表（IIEF-5）评分及阴茎勃起硬度并进行比较研究。结果34例ED患者中显效19例，有效10例，无效5例，总有效率85．3％（29／34）。34例患者治疗前、治疗后及停药6个月后的总体IIEF-5评分分别为（9．9±4．2）分、（19．7±3．8）分和（17．3±3．9）分，IIEF-5评分在治疗前、治疗后和随访6个月后的差异均有统计学意义（P〈0．05）。结论他达拉非可以作为治疗HoLEP术后ED的一线用药。

Objectives To evaluate the efficacy of tadalafil in the treatment of ED after holmium laser enucleation of the prostate（HoLEP）. Methods A total of 34 patients with ED after HoLEP received 3 months of tadalafll treatment and were followed up for 6 months. The IIEF - 5 scores of the patients and Penile erectile hardness were compared before and after the treatment. Results 34 cases of patients with ED markedly improved in 19 cases, effective in 10 cases, invalid in 5 cases, the total effective rate reach 85.3% （29/34）. 34 patients before treatment, after it and withdrawal after 6 months, the general IIEF -5 rating respectively for 9.9 ± 4.2,19. 7 ± 3.8 and 17.3 ± 3.9. The IIEF - 5 scores were statistically significant differences among pre - treatment ,post - treatment and 6 months after drug withdrawal （ P 〈 0.05 ）. Conclusions Tadalafil can be used as a first - line drug for the treatment of ED after HoLEP.