移植肾慢性排斥反应患者治疗前后24h尿蛋白定量、血肌酐及血压水平变化研究

The study on the change of 24h urinary protein,SCr and BP before and after treatment for chronic rejection of kidney transplant patients

目的探讨移植肾慢性排斥反应患者治疗前后24h尿蛋白定量、血肌酐及血压水平变化情况。方法选取行肾移植术后发生移植肾慢性排斥反应的70例患者为实验组，并选取同期行肾移植术后不伴移植肾慢性排斥反应的正常患者70例为对照组。对于发生排斥反应的患者给予冲击治疗和调整免疫抑制剂的剂量逆转排斥反应。将两组患者行肾移植术后的和出院前的24h尿蛋白定量、血肌酐及血压进行研究比较。结果经研究发现，治疗前实验组的24h尿蛋白定量、血肌酐及血压水平明显高于对照组，治疗后降低为基本正常，有显著性差异或有非常显著性差异（P〈0．01）。结论移植肾慢性排斥患者的24h尿蛋白定量、血肌酐及血压水平变化呈现一定的规律性，抗排斥反应治疗可大大改善其水平。研究证明24h尿蛋白定量、血肌酐及血压水平对移植肾慢性排斥反应的临床诊断和治疗具有重要价值。

Objectives To investigate the change before and after treatment of 24h urinary protein ,SCr and BP in chronic rejection of kidney transplant patients. Methods 70 kidney transplant patients in chronic rejection treated with anti - rejection were selected as observation group, and 70 kidney transplant patients without chronic rejection as control group,then the 24h urinary protein,SCr and BP of the two groups before and after the treatment were studied and compared. Results The 24h urinary protein, SCr and BP of the observation group before the treatment were higher than those of control group, and the levels after the treatment at 24 hours declined, and almost equal to those of control group（ P 〈 0.01 ）. There were significant or very significant differences. Conclusions The change of the 24h urinary protein, SCr and BP in the kidney transplant patients in chronic rejection treated with anti -rejection is regular, chronic rejection combined with the treatment of anti -rejection should decrease the levels.