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斯钙素-1在肾细胞癌研究中的进展 被引量：1

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摘要 斯钙素（stanniocalcin，STC）是一种首先在硬骨鱼中发现的糖蛋白激素，该激素由鱼类独有的内分泌腺斯坦尼氏小体分泌，是一个调节局部血清钙磷平衡的重要内分泌因子。最近研究显示，人和哺乳动物中也存在STC，人类STC家族由STC-1和STC-2组成，几乎存在于所有组织，他们主要是作为自／旁分泌因子调节各种生理功能。目前，STC的序列、表达和分布信息仍然缺乏，但最近有证据暗示STC-1和STC-2参与了线粒体和内质网的功能，特别是对氧分压的调节和对未折叠蛋白的反应。近年来的研究发现，STC与人类肿瘤的发生发展也有着十分密切的关系，目前研究重点已转移到癌变方面，侧重于斯钙素的癌症生物学，已有研究探讨了STC作为肿瘤标志物的可行性，本文主要就STC-1作为肾细胞癌肿瘤标志物的研究进展作一综述。
作者 罗俊(综述) 郑军华(审校)
机构地区 同济大学附属第十人民医院泌尿外科
出处 《国际泌尿系统杂志》 2012年第5期652-654,共3页 International Journal of Urology and Nephrology
关键词 癌 肾细胞 糖蛋白类 激素类
分类号 R737.11 [医药卫生—肿瘤]
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参考文献8

  • 1Hasilo CP, McCudden CR, Gillespie JR, et al. Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation. Am j Physiol, 2005, 289(4) : E634 - E642.
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二级参考文献12

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共引文献4

同被引文献21

  • 1Pastore AL, Palleschi G, Silvestri L, et al. Serum and urine bio- markers for human renal cell carcinoma[ J]. Dis Markers, 2015, 2015:251403.
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  • 3Arigami T, Uenosono Y, Ishigami S. et al. Expression of stan- niocalcinl as a potential biomarker of gastric cancer[ J ]. Oncolo- gy, 2012, 83(3) :158-164.
  • 4Meyer HA, T5lle A, Jung M, et al. Identification of stanniocal- cin2 as prognostic marker in renal cell carcinoma[J]. Eur Urol, 2009, 55(3) :669-678.
  • 5Zhang ZH, Wu YG, Qin CK, et al. Stanniocalcin 2 expression predicts poor prognosis of hepatoeellular carcinoma [ J ]. Oncol Lett, 2014, 8(5) :2160-2164.
  • 6Shen X J, Gu K, Shi JP, et al. Increased expression of stannio- ealcin2 is associated with tumor progression after radiotherapy in patients with cervical carcinoma [ J ]. Int J Clin Exp Pathol, 2014, 7(12) :8770-8776.
  • 7Kanellis J, Bick R, Garcia G, et al. Stanniocalcin-1, an inhibi- tor of maerophage chemotaxis and chemokinesis [ J ]. Am J Physi-ol Renal Physiol, 2004, 286 (2) : F356-362.
  • 8Ma X, Gu L, Li H, et al. Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma [ J]. J Transl Med, 2015, 13 ( 1 ) :56-70.
  • 9Law AY, Wong CK. Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia [ J]. Exp Cell Res, 2010, 316(3) :466-476.
  • 10Law AY, Wong CK. Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietiu sig- naling pathways[ J]. Mol Cell Endocrinol, 2013, 15, 374 ( 1- 2) : 73-81.

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国际泌尿系统杂志
2012年 第5期

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