3Ke HM, Huai Q. Structures of calcineurin and its complexes with im- munophilins-immunosuppressants[J]. Biochem Biophys Res Commun, 2003,311 (4) :1 095 - 1 102.
4Herzig S, Neumann J. Effects of serine/threonine protein phosphatases on ion channels in excitable membranes [J ]. Physiol Rev, 2000,80 (1) : 173 - 196.
5Guenm D. Calcineurin: not just a simple protein phosphatase[J]. Biochem Biophys Res Commun, 1997,235 (2) : 271 - 275.
6[16]Macian F, Garcia-Rodriguez C, Rao A. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun[J]. EMBO J, 2000, 19(17):4783 - 4795.
7[17]Garcia-Rodriguez C, Rao A. Nuclear factor of activated T cells(NFAT)-dependent transactivation regulation by the coactivators p300/CREB-binding protein(CBP) [J]. J Exp Med, 1998, 187(12) :2031 - 2036.
8[18]Zhu J, McKeon F. NF-AT activation requires suppression of Crml-dependent export by calcineurin[J]. Nature, 1999,398(6724):256 - 260.
9[19]Kehlenbach RH, Dickmanns A, Gerace L. Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT invitro[J]. J Cell Biol, 1998, 141(4) :863 - 874.
10[1]Sewell TJ, Lam E, Martin MM, et al. Inhibition of calcineurin by a novel FK-506-binding protein [J]. J Biol Chem, 1994, 269(33) :21094 - 21102.
4De Tran QH, Guay E, Chartier S, et al. Tacrolimus in dermatology[J]. J Cutan Med Surg, 2001, 5 (4) : 329-335.
5Panhans-Gross A, Novak N, Kraft S, et al. Human epidermal Langerhaas'cells are targets for the immunosuppressive macrolide tacrollmus (FK506). J Allergy Clin Immunol, 2001, 107(2) : 345-352.
6Vukmanovic-Stejic M, McQuaid A, Birch KE, et al. Relative impact of CD4+ CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis [J]. Br J Dermatol, 2005, 153 (4) : 750-757.
7Fabroni C, Lotti T. Pimecrolimus in dermatology . G Ital Dermatol Venereol, 2009, 144 (3) : 321-325.
8Simpson D, Noble S. Tacrolimus ointment: a review of its use in atopic dermatitis and its clinical potential in other inflammatory skin conditions[J]. Drugs, 2005, 65 (6): 827-858.
9Paller AS, Lebwohl M, Fleischer AB Jr, et al. Tacrolimus ointment is more efective than pimecrolimus cream with a similar safety profile in the treatment of atopic dermatitis: Results from 3 randomized, comparative studies [J]. J Am Acad Dermatol, 2005, 52 (5) : 810-822.
10Hanitin JM, Ling MR, Langley R, et al. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part I, efficacy[J]. J Am Acad Dermatol, 2001, 44 (Suppl 1): S28-S83.
