定量分析肝癌特异性GGT对肝癌诊断和鉴别价值的比较研究

Comparative analysis of hepatoma-specific GGT band quantitative detection in diagnostic and differential values of hepatocellular carcinoma

目的 探讨血清中肝癌特异性GGT同工酶区带 (HSB)、铁蛋白 (SFn)、肿瘤坏死因子 α(TNF α)和脂质结合唾液酸 (LSA)浓度改变在肝癌诊断与鉴别中的临床价值。方法 分别定量检测了肝癌、慢性肝病和肝外肿瘤患者血清HSB、SFn、TNF α和LSA浓度 ,并比较分析了它们的临床意义。结果 肝癌组血清HSB浓度经导管动脉栓塞 (TAE)前明显异常 ,同时也高于慢性肝炎、肝硬化和肝外肿瘤病人 (P <0 0 0 1) ;SFn、LSA和TNF α水平在肝癌组明显高于慢性肝病患者 ,但与其他肿瘤无鉴别价值 ;肝癌组HSB、SFn、LSA和TNF α的阳性率分别为 91 1%、5 3 3 %、67 8%和 86 7%。结论 资料证明HSB定量和定性检测均优于SFn、LSA和TNF α浓度分析 。

Aim To investigate the clinical values of serum hepatoma specific band (HSB) activities of GGT, serum ferritin (SFn) ,lipid associated sialic acid (LSA) and tumor necrosis factor-α levels in diagnosis and differential diagnosis of hepatocellular carcinoma (HCC).Methods The levels of HSB, SFn, LSA and TNF-α were quantitated in patients with HCC or with chronic liver diseases or with extrahepatic tumors. The clinical values of these markers for HCC patients were analyzed in this study. Results The activties of serum HSB in HCC patients before transcatheter arterial embolization were significantly higher than those in patients with chronic liver diseases or with other tumors (P<0001).The levels of SFn, LSA and TNFα in HCC patients were significantly higher than those in chronic liver diseases, but no differentiation was found between HCC group and extrahepatic tumor group. The positive rates of HSB, SFn, LSA and TNFα in HCC group were 91.1%, 53.3%, 67.8% and 86.7%, respectively.Conclusion The present data suggest that the quantitative analysis of serum GGT HSB activities is superior to SFn, LSA and TNFα levels, the combined detection of several markers is helpful to diagnosis and differentiation of HCC.