增殖性玻璃体视网膜病变玻璃体白细胞介素6(IL-6)的定量测定

Measurement of Interleukin 6(IL-6) in Vitreous of Proliferative Vitreoretinopathy

目的 :研究白细胞介素 6 (Interleukin - 6 ,IL - 6 )在增殖性玻璃体视网膜病变 (ProliferativeVitreo retinopathy ,PVR)玻璃体中的表达水平 ,分析IL - 6在PVR中的作用。 方法 :对 37例增殖性玻璃体视网膜病变及 1 2例正常对照玻璃体IL - 6采用双抗夹心法 (ELISA)进行定量测定。结果 :37例PVR玻璃体IL - 6水平为 2 6 4 .87± 1 36 .41 pg/ml,其中 2 2例网脱PVR玻璃体IL - 6水平为 2 6 1 .42± 1 31 .2 7pg/ml,外伤性PVR玻璃体IL - 6水平为 2 97.97±1 41 .5 3pg/ml。正常对照玻璃体IL - 6水平为 35 .6 9± 2 0 .6 4 pg/ml。PVR玻璃体IL - 6水平显著高于正常对照组 (P <0 .0 1 )。IL - 6水平在PVRC、D级最高。结论 :IL - 6在PVR中呈上行性表达 ,参与PVR的发生发展。IL -

Objective:To investigate the expression of Interleukin 6(IL 6) in vitreous of proliferative vitreoretinopathy(PVR),analyse the function of IL 6 in PVR.Methods:The level of IL 6 in vitreous were measured by ELISA method in 37 proliferative vitreoretinopathy cases and 12 normal cases.Results:The IL 6 level in vitreous of 32 PVR was 264.87±136.41pg/ml,IN which the IL 6 in retinal detachment PVR was 261.41±131.27pg/ml,in traumatic PVR was 297.97±141.53pg/ml.Normal contrast IL 6 35.69±20.64pg/ml.The level of IL 6 in vitreous of PVR was higher than normal contrast ( P <0.01).And IL 6 in grade C、D PVR was higher than grade A、B PVR.Conclusion:The expression of IL 6 in vitreous of PVR is up going,and IL 6 participate in the occurrence and development of proliferative vitreoretinopathy.IL 6 may play a main role in the latesed stage of PVR.