补肾化痰法针刺治疗血管性痴呆96例临床观察

Clinical Observation on 96 Cases with Vascular Dementia by Tonifying Kidney and Reducing Phlegm

目的:评价补肾化痰法针刺治疗血管性痴呆的疗效及安全性。方法:采用多中心、随机对照试验的研究方法,治疗组96例给予补肾化痰法针刺治疗,同时配合互动疗法;对照组48例给予甲磺酸双氢麦角毒碱(喜得镇片)口服,连续治疗12周后进行疗效和安全性评价。结果:认知功能(MMSE)、精神指数调查表评分(NPI),治疗组与对照组比较,差异有统计学意义(P<0.05),且治疗期间未发生不良事件。结论:补肾化痰针刺法能明显改善血管性痴呆患者的认知功能与精神指数,具有较高安全性。

Objective： To evaluate the effect and safety on vascular dementia by acupuncture of tonifying kidney and reducing phlegm. Methods： 144 patients with vascular dementia were muhicenter randomized divided into the treatment group （n=96） and the control group （n=48）. The cases of treatment group were treated with acupuncture of tonifying kidney and reducing phlegm,and cooperated with interactive therapy; the control group were treated with Co-dergocrine Mesylate Tablets. The effectiveness and safety were elaluated after treatment of 12 weeks. Results： Compared with control group, the scores of both MMSE and NPI were improved in the treatment group（P〈0.05）, and there were no adverse events during treatment. Conclusion： Acupuncture of tonifying kidney and reducing phlegm can improve cognitive function and tcm symptom in patients with VD.