摘要
OBJECTIVE:The aims of this study were to determine the anti-inflammatory and analgesic effects of Yaotuitong(translation:low back and leg pain) capsules,a Chinese herbal preparation,and the histological changes it induces in experimental rats with chemically induced radicular neuritis.METHODS:Wistar rats were randomly divided into normal,model,Western medicine,and traditional Chinese medicine groups(n=24 per group).We surgically duplicated a chemical radicular neuritis model to simulate lumbar intervertebral disc protrusion.Granuloma formation was measured on postoperative days(PODs) 3,7,14,and 21.Prostaglandin E 2 and 5-hydroxytryptamine(inflammation mediators) levels in the surrounding tissue and the histology of the nerve root were determined on PODs 7 and 14.RESULTS:Yaotuitong capsules significantly reduced prostaglandin E 2(P<0.01) and 5-hydroxytryptamine(P<0.01)levels in tissue surrounding the nerve root.It also inhibited granuloma formation(P<0.05).CONCLUSION:Yaotuitong capsules have anti-in-flammatory and analgesic effects that can alleviate the discomfort of lumbar intervertebral disc protrusion.
OBJECTIVE：The aims of this study were to determine the anti-inflammatory and analgesic effects of Yaotuitong（translation：low back and leg pain） capsules,a Chinese herbal preparation,and the histological changes it induces in experimental rats with chemically induced radicular neuritis.METHODS：Wistar rats were randomly divided into normal,model,Western medicine,and traditional Chinese medicine groups（n=24 per group）.We surgically duplicated a chemical radicular neuritis model to simulate lumbar intervertebral disc protrusion.Granuloma formation was measured on postoperative days（PODs） 3,7,14,and 21.Prostaglandin E 2 and 5-hydroxytryptamine（inflammation mediators） levels in the surrounding tissue and the histology of the nerve root were determined on PODs 7 and 14.RESULTS：Yaotuitong capsules significantly reduced prostaglandin E 2（P〈0.01） and 5-hydroxytryptamine（P〈0.01）levels in tissue surrounding the nerve root.It also inhibited granuloma formation（P〈0.05）.CONCLUSION：Yaotuitong capsules have anti-in-flammatory and analgesic effects that can alleviate the discomfort of lumbar intervertebral disc protrusion.
