三参方对慢性萎缩性胃炎大鼠血浆ET-1和6-k-PGF_1α含量的影响

Effect of Sanshenfang on ET-1 and 6-k-PGF_1α Content in Plasma of Rat with Chronic Atrophic Gastritis Home Helping Hospital of Hebei Province

目的:观察三参方对慢性萎缩性胃炎大鼠血浆内皮素-1(ET-1)和6-酮-前列腺素F1α(6-k-PGF1α)含量的影响,以探讨其慢性萎缩性胃炎的作用机制。方法:将实验大鼠随机分为正常组、模型组、三参方高剂量组、低剂量组和维霉素对照组、三九胃泰对照组,采用复合因素造模法复制大鼠慢性萎缩性胃炎模型,实验8周后,测定各组大鼠血浆ET-1和6-k-PGF1α的含量变化。结果:与正常组比较,模型组大鼠血浆ET-1明显升高、6-k-PGF1α明显降低(P<0.01)。与模型组比较,各治疗组大鼠血浆ET-1明显降低、6-k-PGF1α含量明显升高(P<0.01)。高剂量组ET-1的含量低于三九胃泰组和维霉素组(P<0.05);6-k-PGF1α的含量高于三九胃泰组和维霉素组(P<0.01或P<0.05)。结论:三参方通过降低ET-1、升高6-k-PGF1α的含量、保护血管内皮功能、改善胃黏膜的血液循环治疗慢性萎缩性胃炎。

Objective: to observe the effect of Sanshenfang on endothelin-1(ET-1) and 6-keto-prostaglandin F1α(6-k-PGF1α) content in plasma of rats with chronic atrophic gastritis(CAG) so as to explore the mechanism of action of CAG.Methods: Experimental rats were randomly divided into normal group,model group,high dose of Sanshenfang group,low dose group,Weimeisu group Sanjiu Weitai group.Rat models with CAG were made by composite factors molding method and ET-1 and 6-k-PGF1α content of each group were detected 8 weeks later.Results: compared with normal group,ET-1 increased and 6-k-PGF1α decreased,both obviously(P<0.01);in treatment groups,ET-1 decreased and 6-k-PGF1α increased obviously compared to model group(P<0.01);ET-1 of high dose group was lower than that of Sanjiu Weitai and Weimeisu groups,while 6-k-PGF1a was higher(P<0.01 or P<0.05).Conclusion: Sanshenfang can protect vascular endothelium,improve the blood circulation of gastric mucosa and cure CAG by decreasing ET-1 and increasing 6-k-PGF1α.