CXCL16在大动脉粥样硬化性脑梗死中的研究进展

Advances in CXCL16 Cells in Large Artery Atherosclerosis Stroke

趋化因子CXCL16是新近发现的CXC（α亚族）趋化因子家族新成员。研究发现CXCL16吸引T细胞、自然杀伤细胞向炎症和损伤部位募集，促使细胞之间的黏附和平滑肌细胞增殖，促进巨噬细胞、动脉平滑肌细胞对氧化型低密度脂蛋白的摄取，从而参与大动脉粥样硬化形成。血清CXCL16水平在脑梗死急性期升高，其与大动脉粥样硬化性脑梗死的发生密切相关，也为其预防和治疗提供一个新的研究方向。

Chemotactic factor CXCL16 is a newly discovered which is new member of CXC （ ct subfamily ） chemokine family. Studies have found that CXCL16 attracts T cells, natural killer cells to sites of injury and inflammation. And it promotes adhesion between cells and proliferation of smooth muscle cells and uptake of macrophages, vascular smooth muscle cells on oxidized low density lipoprotein. The serum level of CXCL16 in the acute stage of cerebral infarction is elevated which is closely related to the occurrence of large artery atherosclerosis stroke. And this paper also provides a new research direction for its prevention and treatment .