氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停疗效观察

Observation on effect of aminophylline plus naloxone in treating primary apnea of premature infants

目的观察氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停的疗效。方法 60例原发性呼吸暂停早产儿随机分为两组,在常规治疗基础上,两组均应用氨茶碱,首剂5 mg/kg,12 h后给予维持量2.5 mg/kg,每12 h给药1次;治疗组加用纳洛酮10μg/(kg.h),每8 h或12 h给药1次。结果治疗组总有效率为93.3%,对照组总有效率为70.0%。两组总有效率比较差异有统计学意义(χ2=4.01,P﹤0.05)。结论氨茶碱与纳洛酮联合应用优于单纯用氨茶碱治疗早产儿原发性呼吸暂停。

Objective To observe the effect of aminophylline plus naloxone in treatment of primary apnea of premature infants.Methods 60 premature infants were divided into treatment group and control group randomly.Based on the normal treatment,the two groups were both treated with aminophylline,with a first dose of 5 mg/kg,followed by a maintenance dose of 2.5 mg/kg after 12 hours,once every 12 h;In the treatment group a 10 μg /（kg·h） dose of naloxone was added,every 8 h or 12 h.Results The total effective rate of the treatment group was 93.3% and the control group was 70.0%.The difference between the two groups had statistical value（χ^2=4.01,P〈0.05）.Conclusion Aminophylline plus naloxone in treatment of primary apnea of premature infants provides better benefit compared with aminophylline alone.