原发性高血压患者超敏C反应蛋白与颈动脉粥样硬化斑块的相关性

Correlation between the High-sensitivity C-reactive Protein and Carotid Atherosclerosis Plaque in Patients with Essential Hypertension

目的探讨原发性高血压患者血浆超敏C反应蛋白测值（hs-CRP）与颈动脉粥样硬化斑块的关系。方法 90例原发性高血压患者分为Ⅰ级、Ⅱ级、Ⅲ级3个亚组,同期非高血压患者56例为对照组。对所有患者行血浆hs-CRP测定和颈动脉超声检查。结果 hs-CRP均值、颈动脉粥样硬化斑块检出率、血浆高hs-CRP并发颈动脉粥样硬化斑块检出率高血压组均高于对照组（P〈0.05）;高血压Ⅲ级患者的hs-CRP均值高于Ⅰ级和Ⅱ级者（P〈0.05）;高血压组hs-CRP均值、高hs-CRP检出率与颈动脉粥样硬化斑块检出率呈正相关（r=0.325,P=0.004;r=0.279,P=0.021）,多元回归分析显示,hs-CRP测值（OR=1.128,95%CI1.678~3.986,P〈0.01）是颈动脉粥样硬化斑块检出率的独立危险因素。结论 hs-CRP测值是颈动脉粥样硬化斑块检出率的独立危险因素,高血压患者hs-CRP测值可能与颈动脉粥样硬化斑块的发生率有关。

Objective To analyze the correlation between the value of high-sensitivity C-reactive protein（hs-CRP）and carotid atherosclerosis plaque in patients with essential hypertension（EH）.Methods A total of 90 patients with EH（divided into grade Ⅰ,Ⅱ and Ⅲ） and 56 patients without hypertension were enrolled.The value of hs-CRP was measured and carotid ultrasound was performed in all patients.Results The mean value of hs-CRP,detection rate of carotid atherosclerosis plaque with ultrasound,detection rate of elevated hs-CRP,detection rate of carotid atherosclerosis plaque in group hypertension complicated elevated hs-CRP were all higher than that in non-hypertension group（P 〈 0.05）,and the mean value of hs-CRP in hypertension grade Ⅲ was higher than grade Ⅰ,Ⅱ（P 〈 0.05）;the mean value of hs-CRP and the detection rate of elevated hs-CRP were positively correlation with the detection rate of carotid atherosclerosis plaque in EH patients（r =0.325,P =0.004;r =0.279,P =0.021）;logistic regression analysis showed that the value of hs-CRP（OR=1.128,95%CI 1.678-3.986,P 〈 0.01）was an independent risk factor for the detectable rate of carotid atherosclerosis plaque.Conclusion The hs-CRP value was an independent risk factor for the detection rate of carotid atherosclerosis plaque.The value of hs-CRP in patients with hypertension may correlate with the incidence of carotid atherosclerosis plaque.