藏药降脂诺布治疗高脂血症的药效学研究

THE PHARMACODYNAMIC RESEARCH OF TIBETAN HERBS JIANG ZHI NUO BU ON HYPERLIPEMIA TREATMENT

目的研究藏药降脂诺布对实验性高血脂大鼠的治疗作用。方法大鼠随机分为三组,即正常对照组、预防组和模型组。正常对照组喂鸡粗饲料;预防组添加高脂饲料和藏药降脂诺布;模型组添加高脂饲料。第3周结束时在戊巴比妥钠麻醉条件下分批处死相应组别大鼠取血,测定血清总胆固醇(CHO)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)含量。第4周起正常组同法喂基础饲料,模型组停喂高脂饲料,每日灌胃法予不同治疗药物。于6周末在戊巴比妥钠麻醉条件下分批处死相应组别大鼠,测定血清CHO、TG、HDL-C、LDL-C含量。结果血清CHO、TG、HDL-C、LDL-C水平:对照组、模型组与预防组相比,有统计学意义(P<0.05);对照组、模型组、阳性对照组与治疗组相比,有统计学意义(P<0.05)。结论藏药降脂诺布对大鼠实验性高血脂症有较好的预防和治疗作用。

Objective To research the effect of Tibetan medicine JIANG ZHI NUO BU on the treatment of hyperlipidemia in rts.Methods Rats were randomly divided into three groups,eg.the control group,the preventive group and the model group.The control group was fed with basal diet group（the chickens roughage）;preventive group was adding a high fat diet and the Tibetan herbs JIANG ZHI NUO BU;the model group was adding a high fat diet.At the end of three weeks,the rats were sacrificed under sodium pentobarbital anesthesia;the serum level of CHO,TG,HDL-C and LDL-C concentration were measured.After the 4th week,the normal group fed basal diet with the same fashion,the model group,stop feeding the high fat diet and daily gavage method to different therapeutic agents.After the 6 weeks in the corresponding groups of rats were sacrificed under sodium pentobarbital anesthesia,the serum level of CHO,TG,HDL-C,LDL-C were detected.Results the serum level of CHO,TG,HDL-C and LDL-C in control group,model group showed significant difference with prevention group（P〈0.05）;compared the control group,the model group and the positive control group with the treatment group there were statistical significant difference（P〈0.05）.Conclusion Tibetan herbs JIANG ZHI NUO BU shows better preventive and therapeutic effects on experimental hyperlipidemia.