还原型谷胱甘肽对急性冠脉综合征患者血浆8-异前列腺素F2α的影响

EFFECTS OF REDUCED GLUTATHIONE ON SERUM LEVELS OF 8-ISO-PG F2αIN PATIENTS WITH ACUTE CORONARY SYNDROME

目的探讨应用还原型谷胱甘肽对急性冠脉综合征(ACS)患者血浆异构前列腺素的影响。方法经临床诊断ACS38例,随机分为治疗组和对照组,各19例。对照组给予ACS一般治疗;治疗组除给予ACS一般治疗外,加用还原型谷胱甘肽1.2g/d,共7d。用酶联免疫吸附试验(ELISA)检测二组血清8-iso-PGF2α。结果二组治疗前和对照组治疗前后的血浆异构前列腺素比较差异无统计学意义;治疗组异构前列腺素治疗后较治疗前下降41.7%,差异有统计学意义(P<0.05)。结论应用还原型谷胱甘肽治疗ACS患者能够使异构前列腺素显著下降,提示还原型谷胱甘肽有抗氧化应激作用。

Objective To observe the effects of reduced glutathione on serum levels of 8-iso-PG F2αin patients with acute coronary syndrome（ACS）.Methods Thirty-eight patients who had been diagnosed with ACS were randomized into control group and treatment group.Control group（n=19） just only accepted routine therapy of ACS;treatment group（n=19） accepted reduced glutathione 1.8g per day for 7 days after admission in addition with routine therapy of ACS.The level of 8-iso-PG F2α was measured by ELISA in subjects＇ Plasma.Results There were no statistical difference for the concentration of plasma 8-iso-PG F2α between two groups before medical intervention.So does in control group before and after treatment.The concentration of plasma 8-iso-PG F2α reduced 41.7% in treatment group and the change had a significant statistics with P〈0.05.Conclusions Treated with reduced glutathione in ACS patients after admission the concentration of plasma 8-iso-PG F2α decreases remarkably.This study demonstrates that reduced glutathione could have effects of anti-Oxidative stress.