苯并芘对鱼类免疫毒性作用的研究进展

Advances in the Study of Toxicological Effects of Benzopyrene on Fish Immune System

苯并芘作为多环芳烃类化合物的代表,在自然环境中广泛存在。其主要毒性作用机制是经细胞色素P450单加氧酶代谢活化的产物7,8-二羟基-9,10-环氧苯并芘,这也是产生免疫毒性的关键物质。鱼类的免疫系统处于进化的特殊阶段,本研究以主要免疫因子为切入点,综述了苯并芘对鱼类免疫毒性的作用机制及途径。指出:环境中存在的其他有机污染物对鱼类免疫毒性的作用机理,并就鱼类养殖过程中为应对有机污染物及其他环境因子引起的免疫毒性所使用的免疫增强剂做了简单的介绍。

As a representative of polycyclic aromatic hydrocarbons, Benzopyrene was widespread in the natural environment. It could be metabolized by cytochrome P450 monooxygenase such as CYP1A1. The ultimate metabolite BaP-7,8-dihydrodiol-9,10-epoxide thought to be critical for its immunotoxic activity. Fish immune system was in the special stage of evolution. This paper overviewed the toxicity mechanisms and channels of Benzopyrene on fish immune system from mainly immune factors. And the main immunostimulants used in aquaculture to deal with the immune toxicity caused by organic pollutants and other environmental factors were also briefly discussed.