细胞因子与乙型肝炎肝硬化肝功能分级的相关性

Correlation between cytokines and liver function classification of hepatitis B-associated cirrhosis

目的对细胞因子与乙型肝炎肝硬化肝功能分级的相关性进行临床分析研究。方法分别随机选取2009年2月~2011年2月来本院接受乙型肝炎肝硬化治疗的患者40例,健康体检者40例作为对照组,分别检测两组患者的血清转化生长因子β-1（TGF-β1）、血小板衍生生长因子（PDGF）和γ干扰素（IFN-γ）。结果观察组中TGF-β1及PDGF的含量明显高于对照组（P〈0.05）,IFN-γ的含量明显小于对照组;观察组中Child B级和Child C级患者的TGF-β1及PDGF的含量明显高于Child A级的患者,Child B级和Child C级患者的IFN-γ明显小于Child A级的患者。结论细胞因子水平的检测对于乙型肝炎肝硬化的临床诊断及肝功能分级具有重要的指导意义。

Objective To clinically analyze the correlation between cytokines and liver function classification of hepatitis B-associated cirrhosis.Methods Forty patients with hepatitis B-associated cirrhosis who received treatment in our hospital from February 2009 to February 2011 were randomly selected as study group and another 40 healthy subjects as control group.The serum transforming growth factor beta-1（TGF-β1）,platelet-derived growth factor（PDGF） and interferon-γ（IFN-γ） of the two groups were detected.Results The contents of TGF-β1 and PDGF were significantly higher in the study group than in the control group（P〈0.05） while the content of IFN-γ was significantly lower in the study group than in the control group.The contents of TGF-β1 and PDGF in Child B and Child C patients were significantly higher than Child A patients in the study group.The content of IFN-γ in Child B and Child C patients was significantly lower than Child A patients in the study.Conclusion The detection of cytokine levels is important for the clinical diagnosis of hepatitis B-associated cirrhosis and the classification of liver function.