高压氧治疗脊髓损伤的时间与疗效关系研究

Research on relation between course and effect of hyperbaric oxygen on spinal cord injury

目的分析高压氧治疗脊髓损伤的时间与疗效的关系。方法选择本院2008年2月~2011年2月间收治的脊髓损伤患者130例,随机分为2组,各65例。对照组采取神经外科常规的抗炎抗水肿治疗,并使用神经营养药物;治疗组在对照组基础上加用高压氧治疗不同的疗程。观察高压氧治疗的疗效及不同治疗时间与疗效的关系。结果治疗组总有效率（92.3%）显著高于对照组（75.4%）;随着高压氧治疗的时间的增加,虽然总有效率无显著差异,但显效率显著增加,分别为36.4%（1个疗程）、73.9%（2个疗程）、85.0%（4个疗程）。结论中长疗程的高压氧治疗对脊髓损伤有较好疗效,值得广泛应用于临床脊髓损伤患者的治疗中。

Objective To analyze the relation between course and effect of hyperbaric oxygen on spinal cord injury.Methods A total of 130 patients with spinal cord injury in our hospital from February 2008 to February 2011 were divided into two groups with 65 each.The control group received routine treatment of anti-inflammatory and anti-edema together with neurotrophic drugs.The treatment group received hyperbaric oxygen in addition to the treatment for the control group.The efficacy of hyperbaric oxygen and the relationship between course and effect were observed.Results The total efficacy rate of the treatment group（92.3%） was significantly higher than that of control group（75.4%）.Along with the increase of the time of hyperbaric oxygen therapy,the total efficacy showed no significant increased.But the significantly effective rates increased,they were 36.4%（one course）,73.9%（two courses）,85.0%（four courses）,respectively.Conclusion Moderate-long-term course of hyperbaric oxygen can increase the efficacy for spinal cord injury.It is worthy of clinical application.